BarA 传感器激酶的生理刺激。
The physiological stimulus for the BarA sensor kinase.
机构信息
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
出版信息
J Bacteriol. 2010 Apr;192(7):2009-12. doi: 10.1128/JB.01685-09. Epub 2010 Jan 29.
Abstract
The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.
摘要
双组分信号转导系统 (TCS) BarA/UvrY 激活 CsrB 和 CsrC 非编码 RNA 的转录，这些 RNA 通过隔离 RNA 结合全局调节蛋白 CsrA 起作用。在这里，我们表明代谢终产物甲酸盐和乙酸盐为该 TCS 提供生理刺激，从而将 Csr 系统的转录后调节与细胞的代谢状态联系起来。
相似文献
1
The physiological stimulus for the BarA sensor kinase.BarA 传感器激酶的生理刺激。
J Bacteriol. 2010 Apr;192(7):2009-12. doi: 10.1128/JB.01685-09. Epub 2010 Jan 29.
2
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.大肠杆菌CsrA/CsrB和BarA/UvrY系统的调控电路
J Bacteriol. 2002 Sep;184(18):5130-40. doi: 10.1128/JB.184.18.5130-5140.2002.
3
Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system.全局调控因子CsrA对双组分信号转导系统BarA/UvrY的影响。
J Bacteriol. 2015 Mar;197(5):983-91. doi: 10.1128/JB.02325-14. Epub 2014 Dec 22.
4
The Escherichia coli two-component signal sensor BarA binds protonated acetate via a conserved hydrophobic-binding pocket.大肠杆菌双组分信号传感器 BarA 通过保守的疏水性结合口袋结合质子化的乙酸盐。
J Biol Chem. 2021 Dec;297(6):101383. doi: 10.1016/j.jbc.2021.101383. Epub 2021 Nov 4.
5
Genomic Targets and Features of BarA-UvrY (-SirA) Signal Transduction Systems.BarA-UvrY（-SirA）信号转导系统的基因组靶点与特征
PLoS One. 2015 Dec 16;10(12):e0145035. doi: 10.1371/journal.pone.0145035. eCollection 2015.
6
Circuitry Linking the Catabolite Repression and Csr Global Regulatory Systems of Escherichia coli.连接大肠杆菌分解代谢物阻遏与Csr全局调控系统的电路
J Bacteriol. 2016 Oct 7;198(21):3000-3015. doi: 10.1128/JB.00454-16. Print 2016 Nov 1.
7
Spatiotemporal regulation of the BarA/UvrY two-component signaling system.BarA/UvrY 双组分信号系统的时空调控。
J Biol Chem. 2023 Jun;299(6):104835. doi: 10.1016/j.jbc.2023.104835. Epub 2023 May 17.
8
pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli.大肠杆菌中BarA-UvrY双组分系统的pH依赖性激活
J Bacteriol. 2006 Dec;188(23):8303-6. doi: 10.1128/JB.01052-06. Epub 2006 Sep 15.
9
Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype.大肠杆菌BarA-UvrY双组分系统的遗传与功能特性：BarA传感器HAMP连接区的点突变产生显性负性表型。
J Bacteriol. 2005 Nov;187(21):7317-24. doi: 10.1128/JB.187.21.7317-7324.2005.
10
Identification of YhdA as a regulator of the Escherichia coli carbon storage regulation system.鉴定YhdA为大肠杆菌碳储存调节系统的调节因子。
FEMS Microbiol Lett. 2006 Nov;264(2):232-7. doi: 10.1111/j.1574-6968.2006.00457.x.
引用本文的文献
1
Unlocking the potential of ecofriendly guardians for biological control of plant diseases, crop protection and production in sustainable agriculture.挖掘生态友好型守护者在植物病害生物防治、可持续农业中的作物保护和生产方面的潜力。
3 Biotech. 2025 Apr;15(4):82. doi: 10.1007/s13205-025-04243-3. Epub 2025 Mar 9.
2
Identification of an ArgR-controlled promoter within the outermost region of the ISR mobile element.鉴定位于 ISR 移动元件最外层区域内的 ArgR 控制启动子。
J Bacteriol. 2024 Nov 21;206(11):e0026424. doi: 10.1128/jb.00264-24. Epub 2024 Oct 31.
3
Multifaceted regulation of siderophore synthesis by multiple regulatory systems in Shewanella oneidensis.希瓦氏菌中多种调控系统对铁载体合成的多方面调控
Commun Biol. 2024 Apr 25;7(1):498. doi: 10.1038/s42003-024-06193-7.
4
Current understandings of colibactin regulation.当前对大肠杆菌素调控的理解。
Microbiology (Reading). 2024 Feb;170(2). doi: 10.1099/mic.0.001427.
5
CsrA Positively and Directly Regulates the Expression of the , , and Genes Required for the Luminal Replication of Typhimurium.CsrA 正向且直接调控 沙门氏菌肠腔复制所需的 、 和 基因的表达。
Microbiol Spectr. 2023 Aug 17;11(4):e0151623. doi: 10.1128/spectrum.01516-23. Epub 2023 Jun 26.
6
DksA is a conserved master regulator of stress response in Acinetobacter baumannii.DksA 是鲍曼不动杆菌应激反应的保守主要调控因子。
Nucleic Acids Res. 2023 Jul 7;51(12):6101-6119. doi: 10.1093/nar/gkad341.
7
Roles of Two-Component Signal Transduction Systems in Shigella Virulence.双组分信号转导系统在志贺氏菌毒力中的作用。
Biomolecules. 2022 Sep 18;12(9):1321. doi: 10.3390/biom12091321.
8
Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.大肠杆菌 BarA-UvrY 通过遗传毒素 colibactin 在种间竞争中调节 pks 岛并杀死葡萄球菌。
PLoS Pathog. 2022 Sep 6;18(9):e1010766. doi: 10.1371/journal.ppat.1010766. eCollection 2022 Sep.
9
Deletion and Acetate Reduce Gut Colonization of Crohn's Disease-Associated Adherent-Invasive Escherichia coli by Decreasing Expression of Type 1 Fimbriae.缺失和乙酸盐通过降低 1 型菌毛表达减少克罗恩病相关粘附侵袭性大肠杆菌的肠道定植。
Infect Immun. 2022 Mar 17;90(3):e0066221. doi: 10.1128/iai.00662-21. Epub 2022 Jan 3.
10
The Rsm (Csr) post-transcriptional regulatory pathway coordinately controls multiple CRISPR-Cas immune systems.Rsm（Csr）转录后调控途径协调控制多个 CRISPR-Cas 免疫系统。
Nucleic Acids Res. 2021 Sep 20;49(16):9508-9525. doi: 10.1093/nar/gkab704.
本文引用的文献
1
Evidence against the physiological role of acetyl phosphate in the phosphorylation of the ArcA response regulator in Escherichia coli.关于磷酸乙酰在大肠杆菌ArcA反应调节因子磷酸化过程中生理作用的反证。
J Microbiol. 2009 Oct;47(5):657-62. doi: 10.1007/s12275-009-0087-9. Epub 2009 Oct 24.
2
Small RNA-dependent expression of secondary metabolism is controlled by Krebs cycle function in Pseudomonas fluorescens.小 RNA 依赖的次级代谢表达受荧光假单胞菌克雷布斯循环功能的控制。
J Biol Chem. 2009 Dec 11;284(50):34976-85. doi: 10.1074/jbc.M109.052571. Epub 2009 Oct 19.
3
The RNA binding protein CsrA is a pleiotropic regulator of the locus of enterocyte effacement pathogenicity island of enteropathogenic Escherichia coli.RNA结合蛋白CsrA是肠致病性大肠杆菌肠上皮细胞脱落致病岛位点的多效性调节因子。
Infect Immun. 2009 Sep;77(9):3552-68. doi: 10.1128/IAI.00418-09. Epub 2009 Jul 6.
4
The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins.RNA结合蛋白CsrA通过直接调节GGDEF蛋白的表达来控制环二鸟苷酸代谢。
Mol Microbiol. 2008 Oct;70(1):236-57. doi: 10.1111/j.1365-2958.2008.06411.x. Epub 2008 Aug 18.
5
CsrA inhibits translation initiation of Escherichia coli hfq by binding to a single site overlapping the Shine-Dalgarno sequence.CsrA通过与一个与Shine-Dalgarno序列重叠的单一位点结合，抑制大肠杆菌hfq的翻译起始。
J Bacteriol. 2007 Aug;189(15):5472-81. doi: 10.1128/JB.00529-07. Epub 2007 May 25.
6
CsrB sRNA family: sequestration of RNA-binding regulatory proteins.CsrB小RNA家族：对RNA结合调节蛋白的隔离作用
Curr Opin Microbiol. 2007 Apr;10(2):156-63. doi: 10.1016/j.mib.2007.03.007. Epub 2007 Mar 23.
7
Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E.鉴定一种新型调控蛋白（CsrD），该蛋白靶向全局调控RNA CsrB和CsrC，使其被核糖核酸酶E降解。
Genes Dev. 2006 Sep 15;20(18):2605-17. doi: 10.1101/gad.1461606.
8
pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli.大肠杆菌中BarA-UvrY双组分系统的pH依赖性激活
J Bacteriol. 2006 Dec;188(23):8303-6. doi: 10.1128/JB.01052-06. Epub 2006 Sep 15.
9
The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract.大肠杆菌的BarA-UvrY双组分系统是尿路中的一种毒力决定因素。
BMC Microbiol. 2006 Mar 10;6:27. doi: 10.1186/1471-2180-6-27.
10
CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae.CsrA和三种冗余小RNA调节霍乱弧菌中的群体感应。
Mol Microbiol. 2005 Nov;58(4):1186-202. doi: 10.1111/j.1365-2958.2005.04902.x.
Zotero 插件