Rougon G, Alterman L A, Dennis K, Guo X J, Kinnon C
Faculté des Sciences de Luminy, Biologié de la Différenciation Cellulaire, Marseille.
Eur J Immunol. 1991 Jun;21(6):1397-402. doi: 10.1002/eji.1830210611.
The murine heat-stable antigen (HSA) and the p31 antigen are cell surface glycoconjugates which are transiently expressed during the development and differentiation of the hematolymphoid and neural cell lineages, respectively. We show here that monoclonal antibodies which react with these two species recognize a common antigenic determinant which is expressed on both HSA and p31, and the HSA and p31 share a common protein core. Differences in the molecular weights of the antigens most likely reflect variations in the extent of post-translational modifications. From these studies we conclude that these antigens are members of the same family of heat-stable antigens. Our results lead us to speculate on how these molecules are related, their function, and what role they play in cellular differentiation in hematolymphoid and neural cell development.
小鼠热稳定抗原（HSA）和p31抗原是细胞表面糖缀合物，分别在血液淋巴和神经细胞谱系的发育和分化过程中短暂表达。我们在此表明，与这两种物质反应的单克隆抗体识别一种共同的抗原决定簇，该决定簇在HSA和p31上均有表达，并且HSA和p31共享一个共同的蛋白质核心。抗原分子量的差异很可能反映了翻译后修饰程度的变化。从这些研究中我们得出结论，这些抗原是同一热稳定抗原家族的成员。我们的结果促使我们推测这些分子如何相关、它们的功能以及它们在血液淋巴和神经细胞发育中的细胞分化中起什么作用。
