Research Centre for Prevention and Health, Glostrup University Hospital, Building 84/85, Ndr. Ringvej 57, Glostrup 2600, Denmark.
Occup Environ Med. 2010 May;67(5):318-22. doi: 10.1136/oem.2008.043091.
To investigate the effect of work pressure and job influence on the development of ischaemic heart disease (IHD) in women.
The effect of work pressure and job influence on the 15-year incidence of IHD in women participating in the Danish Nurse Cohort Study was prospectively studied. A total of 12 116 participants, aged 45-64 years, were examined in 1993 using a questionnaire and were followed by individual linkage in the National Register of Hospital Discharges to the beginning of 2008. Work pressure, job influence, occupational characteristics, demographic factors and known biological and behavioural risk factors for IHD were collected at baseline.
During follow-up, 580 participants were hospitalised with IHD. In the fully adjusted model, nurses who reported work pressure to be much too high had a 1.4-fold increased risk of incident IHD (95% CI 1.04 to 1.81) compared with nurses who reported work pressure to be suitable. A tendency towards a dose-response effect was found. Age-stratified analysis showed that this effect was significant only among the younger nurses (<51 years old at baseline). No association was found between job influence and IHD.
In this study we find that work pressure that is too high is a significant risk factor for IHD in younger female employees (<51 years of age). The results should be taken into account in the planning of primary prevention.
探讨工作压力和职业影响对女性缺血性心脏病（IHD）发展的影响。
前瞻性研究丹麦护士队列研究中参与女性的工作压力和职业影响对 IHD 15 年发病率的影响。共有 12116 名年龄在 45-64 岁的参与者在 1993 年通过问卷调查进行了检查，并通过个人链接在国家住院患者登记处追踪至 2008 年初。在基线时收集了工作压力、职业影响、职业特征、人口统计学因素以及 IHD 的已知生物和行为风险因素。
在随访期间，580 名参与者因 IHD 住院。在完全调整的模型中，与报告工作压力适中的护士相比，报告工作压力过高的护士发生 IHD 的风险增加了 1.4 倍（95%CI 1.04 至 1.81）。发现存在剂量反应关系的趋势。年龄分层分析表明，这种效应仅在年轻护士（基线时<51 岁）中显著。职业影响与 IHD 之间没有关联。
在这项研究中，我们发现过高的工作压力是年轻女性员工（<51 岁）发生 IHD 的一个重要危险因素。在进行初级预防规划时应考虑这些结果。
