College of Science, King Saud University, Riyadh, Saudi Arabia.
Int J Toxicol. 2010 May-Jun;29(3):313-7. doi: 10.1177/1091581810364852.
This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl(2))-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl(2) at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg/kg body weight, and the animals were sacrificed at 24 hours following HgCl(2) injection. A separate batch of animals received HgCl(2) (2 mg/kg) with or without DMPS (100 mg/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl(2) resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl(2). Pretreatment with DMPS offered statistically significant protection against HgCl(2)-induced alterations in various urinary carnitine fractions in rats.
本研究旨在探讨 2,3-二巯基-1-丙磺酸（DMPS）对氯化汞（HgCl2）诱导的各种肉碱（包括游离肉碱[FC]、酰基肉碱[AC]和总肉碱[TC]）尿排泄改变的影响。不同组别的雄性 Wistar 大鼠分别用 0.1、0.5、1.0、2.0 和 3.0 mg/kg 体重的 HgCl2 处理，在 HgCl2 注射后 24 小时处死动物。另一组动物接受 HgCl2（2 mg/kg）和/或 DMPS（100 mg/kg）处理，并在给药后 24 或 48 小时处死。HgCl2 给药导致大鼠尿 FC、AC 和 TC 的排泄显著增加，且呈剂量依赖性。然而，HgCl2 显著降低了尿 AC:FC 的比值。DMPS 预处理可显著对抗 HgCl2 诱导的大鼠各种尿肉碱变化。
