Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Obesity (Silver Spring). 2010 Dec;18(12):2255-9. doi: 10.1038/oby.2010.96. Epub 2010 May 6.
High respiratory quotient (RQ) has been associated with fat mass (FM) gain in some, but not all studies. Variability among results may reflect differences in the RQ variable measured (fasting vs. 24-h) or may be due to differences in control for factors that affect RQ, such as diet, energy balance, circulating insulin, and insulin sensitivity. The objective of this study was to determine whether different RQ values (fasting, sleeping, nonsleeping, and 24-h) would predict change in FM over 2 years in obesity-prone women, controlling for diet and adjusting for energy balance, circulating insulin, and insulin sensitivity. Participants were 33 previously overweight premenopausal women. Fasting, sleeping, nonsleeping, and 24-h RQ values were measured during controlled-diet conditions by respiratory chamber calorimetry. Intravenous glucose tolerance tests were also performed to adjust for fasting insulin, acute insulin response to glucose, and insulin sensitivity. Over the following 2 years, changes in FM were tracked annually by dual energy X-ray absorptiometry. High nonsleeping RQ (NSRQ) predicted 2-year change in FM independently of energy balance, circulating insulin, and insulin sensitivity. This observation suggests that low postprandial fat oxidation may uniquely predispose obesity-prone individuals to accrual of adipose tissue.
高呼吸商 (RQ) 与一些研究中的脂肪量 (FM) 增加有关，但并非所有研究都如此。结果的可变性可能反映了所测量的 RQ 变量的差异（空腹与 24 小时），也可能是由于影响 RQ 的因素（如饮食、能量平衡、循环胰岛素和胰岛素敏感性）的控制存在差异。本研究的目的是确定在控制饮食的情况下，不同的 RQ 值（空腹、睡眠、非睡眠和 24 小时）是否可以预测肥胖易感性女性在 2 年内 FM 的变化，并调整能量平衡、循环胰岛素和胰岛素敏感性。参与者为 33 名超重的绝经前妇女。通过呼吸室量热法在控制饮食条件下测量空腹、睡眠、非睡眠和 24 小时 RQ 值。还进行了静脉葡萄糖耐量试验，以调整空腹胰岛素、葡萄糖急性胰岛素反应和胰岛素敏感性。在接下来的 2 年中，通过双能 X 射线吸收仪每年跟踪 FM 的变化。高非睡眠 RQ (NSRQ) 可独立于能量平衡、循环胰岛素和胰岛素敏感性预测 2 年的 FM 变化。这一观察结果表明，餐后脂肪氧化减少可能会使肥胖易感性个体特别容易积累脂肪组织。
