气体栓塞治疗中声致微泡汽化的动力学
Dynamics of acoustic droplet vaporization in gas embolotherapy.
作者信息
Qamar Adnan, Wong Zheng Z, Fowlkes J Brian, Bull Joseph L
出版信息
Appl Phys Lett. 2010 Apr 5;96(14):143702. doi: 10.1063/1.3376763. Epub 2010 Apr 7.
Abstract
Acoustic droplet vaporization is investigated in a theoretical model. This work is motivated by gas embolotherapy, a developmental cancer treatment involving tumor infarction with gas microbubbles that are selectively formed from liquid droplets. The results indicate that there exists a threshold value for initial droplet size below which the bubble evolution is oscillatory and above which it is smooth and asymptotic, and show that the vaporization process affects the subsequent microbubble expansion. Dampening of the bubble expansion is observed for higher viscosity and surface tension, with effects more pronounced for droplet size less than 6 mum in radius.
摘要
在一个理论模型中对声滴汽化进行了研究。这项工作的动机来自气体栓塞疗法，这是一种正在发展的癌症治疗方法，涉及通过由液滴选择性形成的气体微泡使肿瘤梗死。结果表明，初始液滴尺寸存在一个阈值，低于该阈值时气泡演化是振荡的，高于该阈值时则是平滑且渐近的，并且表明汽化过程会影响随后的微泡膨胀。对于较高的粘度和表面张力，观察到气泡膨胀受到抑制，对于半径小于6微米的液滴尺寸，这种影响更为明显。
相似文献
1
Dynamics of acoustic droplet vaporization in gas embolotherapy.气体栓塞治疗中声致微泡汽化的动力学
Appl Phys Lett. 2010 Apr 5;96(14):143702. doi: 10.1063/1.3376763. Epub 2010 Apr 7.
2
Vaporization dynamics of volatile perfluorocarbon droplets: a theoretical model and in vitro validation.挥发性全氟化碳液滴的蒸发动力学：理论模型与体外验证
Med Phys. 2014 Oct;41(10):102901. doi: 10.1118/1.4894804.
3
Evolution of acoustically vaporized microdroplets in gas embolotherapy.气体栓塞治疗中声学汽化微滴的演变
J Biomech Eng. 2012 Mar;134(3):031010. doi: 10.1115/1.4005980.
4
Direct numerical simulations of micro-bubble expansion in gas embolotherapy.气体栓塞治疗中微泡扩张的直接数值模拟
J Biomech Eng. 2004 Dec;126(6):745-59. doi: 10.1115/1.1824131.
5
An enhanced, rational model to study acoustic vaporization dynamics of a bubble encapsulated within a nonlinearly elastic shell.一种用于研究封装在非线性弹性壳内气泡的声汽化动力学的改进的、合理的模型。
Ultrason Sonochem. 2022 Feb;83:105948. doi: 10.1016/j.ultsonch.2022.105948. Epub 2022 Feb 8.
6
Microbubble expansion in a flexible tube.柔性管中的微泡膨胀。
J Biomech Eng. 2006 Aug;128(4):554-63. doi: 10.1115/1.2206200.
7
Characterization of acoustic droplet vaporization for control of bubble generation under flow conditions.流动条件下用于控制气泡产生的声滴汽化特性研究。
Ultrasound Med Biol. 2014 Mar;40(3):551-61. doi: 10.1016/j.ultrasmedbio.2013.10.020. Epub 2014 Jan 13.
8
Characterization of Bioeffects on Endothelial Cells under Acoustic Droplet Vaporization.声学微滴汽化对内皮细胞生物效应的表征
Ultrasound Med Biol. 2015 Dec;41(12):3241-52. doi: 10.1016/j.ultrasmedbio.2015.07.019. Epub 2015 Sep 26.
9
Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization.声击穿空化泡的时空细胞生物效应。
Theranostics. 2018 Nov 10;8(20):5731-5743. doi: 10.7150/thno.28782. eCollection 2018.
10
Numerical Study of Bubble Area Evolution During Acoustic Droplet Vaporization-Enhanced HIFU Treatment.声滴汽化增强型高强度聚焦超声治疗中气泡面积演变的数值研究
J Biomech Eng. 2017 Sep 1;139(9). doi: 10.1115/1.4037150.
引用本文的文献
1
The Role of Acoustic Parameters in Droplet Vaporization of Perfluoropentane Nanodroplets for Applications.声学参数在全氟戊烷纳米液滴用于相关应用的液滴蒸发中的作用
ACS Appl Mater Interfaces. 2025 Jul 2;17(26):37562-37576. doi: 10.1021/acsami.5c05638. Epub 2025 Jun 16.
2
Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions.超声空化泡的成核与动力学：概念、应用与新方向综述。
Z Med Phys. 2023 Aug;33(3):387-406. doi: 10.1016/j.zemedi.2023.01.004. Epub 2023 Feb 10.
3
Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release.声致液滴汽化法制备声响应性支架中稳定和瞬态气泡的形成：顺序释放中的理论与应用。
Ultrason Sonochem. 2021 Apr;72:105430. doi: 10.1016/j.ultsonch.2020.105430. Epub 2020 Dec 24.
4
Numerical investigation of acoustic vaporization threshold of microdroplets.微滴声蒸发阈值的数值研究
Ultrason Sonochem. 2021 Mar;71:105361. doi: 10.1016/j.ultsonch.2020.105361. Epub 2020 Oct 21.
5
Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.在小鼠肝细胞癌模型中，联合气体栓塞和化疗可导致肿瘤完全消退。
APL Bioeng. 2020 Sep 8;4(3):036106. doi: 10.1063/5.0005329. eCollection 2020 Sep.
6
Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization.利用声滴汽化对声学响应性支架中的微观力学和微观结构进行时空控制。
Soft Matter. 2020 Jul 22;16(28):6501-6513. doi: 10.1039/d0sm00753f.
7
Acoustic Droplet Vaporization in Acoustically Responsive Scaffolds: Effects of Frequency of Excitation, Volume Fraction and Threshold Determination Method.声响应支架中的声空化液滴：激励频率、体积分数和阈值确定方法的影响。
Ultrasound Med Biol. 2019 Dec;45(12):3246-3260. doi: 10.1016/j.ultrasmedbio.2019.08.018. Epub 2019 Sep 25.
8
Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma.使用声击穿技术对肝癌模型进行微创气体栓塞。
Sci Rep. 2019 Jul 30;9(1):11040. doi: 10.1038/s41598-019-47309-y.
9
Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.声频液滴汽化介导的模拟血液、血浆和血液中溶解氧清除。
Ultrason Sonochem. 2019 Sep;56:114-124. doi: 10.1016/j.ultsonch.2019.03.029. Epub 2019 Mar 28.
10
Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization.声击穿空化泡的时空细胞生物效应。
Theranostics. 2018 Nov 10;8(20):5731-5743. doi: 10.7150/thno.28782. eCollection 2018.
本文引用的文献
1
The application of microbubbles for targeted drug delivery.微泡在靶向给药中的应用。
Expert Opin Drug Deliv. 2007 Sep;4(5):475-93. doi: 10.1517/17425247.4.5.475.
2
Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent.声滴汽化阈值：脉冲持续时间和造影剂的影响
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 May;54(5):933-46. doi: 10.1109/tuffc.2007.339.
3
Cavitation bubble dynamics inside liquid drops in microgravity.微重力环境下液滴内的空化泡动力学
Phys Rev Lett. 2006 Sep 1;97(9):094502. doi: 10.1103/PhysRevLett.97.094502.
4
Microbubble expansion in a flexible tube.柔性管中的微泡膨胀。
J Biomech Eng. 2006 Aug;128(4):554-63. doi: 10.1115/1.2206200.
5
Cardiovascular bubble dynamics.心血管气泡动力学
Crit Rev Biomed Eng. 2005;33(4):299-346. doi: 10.1615/critrevbiomedeng.v33.i4.10.
6
Direct numerical simulations of micro-bubble expansion in gas embolotherapy.气体栓塞治疗中微泡扩张的直接数值模拟
J Biomech Eng. 2004 Dec;126(6):745-59. doi: 10.1115/1.1824131.
7
On the acoustic vaporization of micrometer-sized droplets.关于微米级液滴的声致汽化
J Acoust Soc Am. 2004 Jul;116(1):272-81. doi: 10.1121/1.1755236.
Zotero 插件