气体栓塞治疗中声致微泡汽化的动力学
Dynamics of acoustic droplet vaporization in gas embolotherapy.
作者信息
Qamar Adnan, Wong Zheng Z, Fowlkes J Brian, Bull Joseph L
出版信息
Appl Phys Lett. 2010 Apr 5;96(14):143702. doi: 10.1063/1.3376763. Epub 2010 Apr 7.
Abstract
Acoustic droplet vaporization is investigated in a theoretical model. This work is motivated by gas embolotherapy, a developmental cancer treatment involving tumor infarction with gas microbubbles that are selectively formed from liquid droplets. The results indicate that there exists a threshold value for initial droplet size below which the bubble evolution is oscillatory and above which it is smooth and asymptotic, and show that the vaporization process affects the subsequent microbubble expansion. Dampening of the bubble expansion is observed for higher viscosity and surface tension, with effects more pronounced for droplet size less than 6 mum in radius.
摘要
在一个理论模型中对声滴汽化进行了研究。这项工作的动机来自气体栓塞疗法，这是一种正在发展的癌症治疗方法，涉及通过由液滴选择性形成的气体微泡使肿瘤梗死。结果表明，初始液滴尺寸存在一个阈值，低于该阈值时气泡演化是振荡的，高于该阈值时则是平滑且渐近的，并且表明汽化过程会影响随后的微泡膨胀。对于较高的粘度和表面张力，观察到气泡膨胀受到抑制，对于半径小于6微米的液滴尺寸，这种影响更为明显。
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