载有硅纳米颗粒的脂双层用于基因传递。
Silica nanoparticle supported lipid bilayers for gene delivery.
机构信息
Center for Micro-Engineered Materials, University of New Mexico, Albuquerque, NM, USA.
出版信息
Chem Commun (Camb). 2009 Sep 14(34):5100-2. doi: 10.1039/b911472f. Epub 2009 Jul 28.
Abstract
Silica nanoparticle supported cationic lipids can effectively bind plasmid DNAs and transfect mammalian cells with an efficiency that depends on both the particle size and lipid composition; here the gene delivery and expression process has been confirmed by confocal fluorescence microscopy.
摘要
纳米二氧化硅载体的阳离子脂质体能够有效地结合质粒 DNA，并通过其粒径和脂质组成的影响有效地转染哺乳动物细胞；本文通过共聚焦荧光显微镜证实了基因的传递和表达过程。
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