Liu Juewen, Jiang Xingmao, Ashley Carlee, Brinker C Jeffrey
Center for Micro-Engineered Materials, University of New Mexico, Albuquerque, New Mexico 87106, USA.
J Am Chem Soc. 2009 Jun 10;131(22):7567-9. doi: 10.1021/ja902039y.
The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery.
纳米颗粒内货物的装载、容纳以及将其有效递送至细胞是纳米医学中的一项主要挑战。我们报告了游离脂质与介孔二氧化硅纳米颗粒支撑的脂质双层之间的脂质交换,这是一种有效容纳货物、控制电荷并将其定向递送至哺乳动物细胞的方法。文中展示了一种膜不透性染料(钙黄绿素)和一种化疗药物(阿霉素)的递送情况。交换后的脂质双层可最大程度减少药物过早释放,并且支撑脂质双层上的整体正电荷可实现增强递送。