沸水催化的中性和选择性 N-Boc 脱保护。
Boiling water-catalyzed neutral and selective N-Boc deprotection.
机构信息
State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Chem Commun (Camb). 2009 Sep 14(34):5144-6. doi: 10.1039/b910239f. Epub 2009 Jul 31.
DOI:10.1039/b910239f
PMID:20448974
Abstract
A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.
摘要
本文报道了一种脱除各种类型氮原子上 Boc 基团的通用方法，初步研究表明，在高温条件下，水作为一种双酸/碱催化剂参与反应。
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