Tuderman L, Risteli J, Miettinen T A, Kivirikko K I
Eur J Clin Invest. 1977 Dec;7(6):537-41. doi: 10.1111/j.1365-2362.1977.tb01648.x.
The concentration of serum immunoreactive prolyl hydroxylase (SIRPH) was measured in thirty patients with chronic active hepatitis, thirteen with primary biliary cirrhosis, four with alcoholic or idiopathic cirrhosis, and four with acute hepatitis; the values were compared with those in twenty-three control subjects. Increases in SIRPH were found in all the groups with liver diseases, individual values being highest in primary biliary cirrhosis in which about two-thirds of patients had values more than two standard deviations above the mean value in the control subjects. No correlation was found between SIRPH and other tests of liver function or some routine laboratory tests. SIRPH may reflect some hitherto unknown of unmeasured process in the diseased hepatic cells.
对30例慢性活动性肝炎患者、13例原发性胆汁性肝硬化患者、4例酒精性或特发性肝硬化患者以及4例急性肝炎患者测定了血清免疫反应性脯氨酰羟化酶（SIRPH）浓度；并将这些值与23名对照受试者的值进行了比较。所有肝病组均发现SIRPH升高，原发性胆汁性肝硬化患者的个体值最高，其中约三分之二患者的值高于对照受试者平均值两个标准差以上。未发现SIRPH与其他肝功能检查或一些常规实验室检查之间存在相关性。SIRPH可能反映了病变肝细胞中一些迄今未知或未测量的过程。
