McPhie J L
Hepatogastroenterology. 1980 Aug;27(4):277-82.
The activity of prolyl hydroxylase was measured in liver tissue obtained from a small series of patients with a variety of liver disease. Enzyme levels were marginally elevated in patients with fatty liver and viral hepatitis, conditions not normally associated with progressive fibrosis. In some patients with alcoholic hepatitis and in all patients with cirrhosis and chronic active hepatitis, there was a marked increase in enzyme activity. Patients with conditions characterised by high liver prolyl hydroxylase levels showed histological evidence of extensive hepatic fibrosis and also significant increases in the serum values of glutamate dehydrogenase and gamma-glutamyl-transpeptidase. Prolyl hydroxylase activity was not detected in serum.
在一小部分患有各种肝脏疾病的患者所获取的肝脏组织中，检测了脯氨酰羟化酶的活性。在脂肪肝和病毒性肝炎患者中，酶水平略有升高，而这些病症通常与进行性纤维化无关。在一些酒精性肝炎患者以及所有肝硬化和慢性活动性肝炎患者中，酶活性显著增加。肝脏脯氨酰羟化酶水平高的患者表现出广泛肝纤维化的组织学证据，同时谷氨酸脱氢酶和γ-谷氨酰转肽酶的血清值也显著升高。血清中未检测到脯氨酰羟化酶活性。
