Waszkiewicz Napoleon, Popławska Regina, Konarzewska Beata, Szajda Sławomir Dariusz, Galińska Beata, Rutkowski Piotr, Leśniak Radosław, Szulc Agata
Klinika Psychiatrii UM w Białymstoku.
Psychiatr Pol. 2010 Jan-Feb;44(1):137-46.
An increasing number of new biomarkers of alcohol abuse appear in the literature. The most commonly used biomarkers (5-hydroxytryptophol, fatty acid ethyl esters, ethyl glucuronide, phosphatidyl ethanol, ethyl sulphate, mitochondrial aspartate aminotransferase, carbohydrate deficient transferrin, acetaldehyde adducts, beta-hexosaminidase, and sialic acid) were described. Then other known and less known biomarkers associated with alcohol abuse were described in brief (e.g. acetaldehyde, acetate, methanol, alpha-amino-n-butyric acid, dolichol, proteomics). Their sensitivity and specificity is generally higher than that of traditional biomarkers. The time of detection in biological fluids occur from one day to few months after alcohol consumption. Hence, their usefulness in clinical practice as well as in experimental studies is increasing.
文献中出现了越来越多关于酒精滥用的新生物标志物。文中描述了最常用的生物标志物（5-羟色醇、脂肪酸乙酯、乙基葡萄糖醛酸苷、磷脂酰乙醇、硫酸乙酯、线粒体天冬氨酸转氨酶、缺糖转铁蛋白、乙醛加合物、β-己糖胺酶和唾液酸）。随后简要介绍了其他与酒精滥用相关的已知和鲜为人知的生物标志物（如乙醛、乙酸盐、甲醇、α-氨基-n-丁酸、多萜醇、蛋白质组学）。它们的敏感性和特异性通常高于传统生物标志物。在生物体液中的检测时间在饮酒后一天至数月不等。因此，它们在临床实践以及实验研究中的用途正在增加。
