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[Study on solubility of Chinese herbal compound by solubility parameter].

作者信息

Wu Dezhi, Chen Lihua, Wang Sen, Zhu Weifeng, Guan Yongmei

机构信息

Key Laboratory for Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):444-8. doi: 10.4268/cjcmm20100410.

DOI:10.4268/cjcmm20100410
PMID:20450042
Abstract

OBJECTIVE

To demonstrate the solubility of Chinese herbal compound with solubility parameters.

METHOD

The solubility parameters of Liangfu effective components and Liangfu compound were determined by inverse gas chromatograph (IGC) and group contribution. Hansen ball was plotting by HSPiP, which could be used to investigate the solubility of Liangfu effective components and Liangfu compound in different solvents. And the results were verified by approximate solubility.

RESULT

Liangfu effective components and Liangfu compound could be dissolved in chloroform, ethyl acetate, acetone, octanol and ether, and were slightly soluble in glycerol, methanol, ethanol and propanediol, but could not be dissolved in water. They were all liposoluble, and the results were the same as the test results of the approximate solubility.

CONCLUSION

The solubility of Chinese herbal compound can be expressed by solubility parameters, and it is accurate, convenient and visual.

摘要

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