Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine (Institute of Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, 510006, China; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Chinese Medicine for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
J Ethnopharmacol. 2024 Mar 1;321:117484. doi: 10.1016/j.jep.2023.117484. Epub 2023 Nov 25.
Diabetes is a common chronic disease. Chinese herbal medicine (CHM) has a history of several thousand years in the treatment of diabetes, and active components with hypoglycemic effects extracted from various CHM, such as polysaccharides, flavonoids, terpenes, and steroidal saponins, have been widely used in the treatment of diabetes.
Research exploring the potential of various CHM compounds to regulate the mitochondrial respiratory chain complex to improve type 2 diabetes mellitus (T2DM).
The literature data were primarily obtained from authoritative databases such as PubMed, CNKI, Wanfang, and others within the last decade. The main keywords used include "type 2 diabetes mellitus", "Chinese medicine", "Chinese herbal medicine", "mitochondrial respiratory chain complex", and "mitochondrial dysfunction".
Chinese herbal medicine primarily regulates the activity of mitochondrial respiratory chain complexes in various tissues such as liver, adipose tissue, skeletal muscle, pancreatic islets, and small intestine. It improves cellular energy metabolism through hypoglycemic, antioxidant, anti-inflammatory and lipid-modulating effects. Different components of CHM can regulate the same mitochondrial respiratory chain complexes, while the same components of a particular CHM can regulate different complex activities. The active components of CHM target different mitochondrial respiratory chain complexes, regulate their aberrant changes and effectively improve T2DM and its complications.
Chinese herbal medicine can modulate the function of mitochondrial respiratory chain complexes in various cell types and exert their hypoglycemic effects through various mechanisms. CHM has significant therapeutic potential in regulating mitochondrial respiratory chain complexes to improve T2DM, but further research is needed to explore the underlying mechanisms and conduct clinical trials to assess the safety and efficacy of these medications. This provides new perspectives and opportunities for personalized improvement and innovative developments in diabetes management.
糖尿病是一种常见的慢性疾病。中药在治疗糖尿病方面已有几千年的历史，从各种中药中提取的具有降血糖作用的活性成分，如多糖、类黄酮、萜类、甾体皂苷等，已广泛应用于糖尿病的治疗。
探索各种中药化合物调节线粒体呼吸链复合体的潜力，以改善 2 型糖尿病（T2DM）。
文献资料主要来源于近十年内 PubMed、CNKI、万方等权威数据库，主要关键词包括“2 型糖尿病”、“中药”、“中草药”、“线粒体呼吸链复合体”、“线粒体功能障碍”等。
中药主要通过降血糖、抗氧化、抗炎和调脂作用调节肝、脂肪组织、骨骼肌、胰岛和小肠等各种组织中线粒体呼吸链复合体的活性。不同的中药成分可以调节相同的线粒体呼吸链复合体，而同一中药的相同成分可以调节不同的复合体活性。中药的活性成分靶向不同的线粒体呼吸链复合体，调节其异常变化，有效改善 T2DM 及其并发症。
中药可以调节各种细胞类型中线粒体呼吸链复合体的功能，通过多种机制发挥其降血糖作用。中药在调节线粒体呼吸链复合体改善 T2DM 方面具有显著的治疗潜力，但仍需要进一步研究探索其潜在机制，并进行临床试验评估这些药物的安全性和疗效。这为糖尿病管理的个性化改善和创新发展提供了新的视角和机会。
