Department of Radiology, Charité - Universitätsmedizin Berlin, Germany.
Clin Radiol. 2010 Jun;65(6):460-4. doi: 10.1016/j.crad.2010.02.007.
To evaluate the impact of butylscopolamine on the quality of magnetic resonance imaging (MRI) images of the prostate.
Eighty-two MRI examinations of the prostate were retrospectively analysed. MRI was performed with a combined endorectal/body phased-array coil including proton density-weighted (PD) sequence, T1-weighted turbo spin-echo (TSE)-sequence, and T2-weighted TSE-sequences. Forty milligrams of butylscopolamine was administered intramuscularly in 31 patients (im-group) and intravenously in 30 patients (iv-group). Twenty-one patients did not receive premedication with butylscopolamine (ø-group). Overall image quality, delineation of the bowel wall, and visualization of the prostate, neurovascular bundle, and pelvic lymph nodes were evaluated qualitatively using a five-point scale (from 1=excellent to 5=non-diagnostic/structure not discernible). Motion artefacts within the endorectal coil were quantified by baseline adjusted signal intensities inside the endorectal coil area.
Delineation of the bowel wall using the PD-sequence was significantly improved after both intramuscular and intravenous butylscopolamine administration (ø-group: 3.6+/-0.7; im-group: 2.9+/-0.7; iv-group: 2.9+/-0.7; p=0.001). However, there were no significant differences in motion artefacts measured within the endorectal coil (ø-group: 1.18+/-0.14; im-group: 1.15+/-0.11; iv-group: 1.12+/-0.06; p=0.39). There were also no significant differences in qualitative assessment of visualization of the prostate, neurovascular bundle, pelvic lymph nodes, and of overall image quality between the study groups.
: In conclusion, butylscopolamine had only a small effect on image quality and is not mandatory for MRI of the prostate.
评估丁溴东莨菪碱对前列腺磁共振成像（MRI）图像质量的影响。
回顾性分析 82 例前列腺 MRI 检查。MRI 采用直肠内/体相控阵线圈进行，包括质子密度加权（PD）序列、T1 加权 turbo 自旋回波（TSE）序列和 T2 加权 TSE 序列。31 例患者（im 组）肌肉注射 40mg 丁溴东莨菪碱，30 例患者（iv 组）静脉注射丁溴东莨菪碱。21 例患者未接受丁溴东莨菪碱（ø 组）预处理。使用 5 分制（1=极好，5=无法诊断/结构不可辨）对整体图像质量、肠壁勾画和前列腺、神经血管束、盆腔淋巴结的显示情况进行定性评估。通过直肠内线圈区域内的基线调整信号强度来量化直肠内线圈内的运动伪影。
PD 序列中肠壁的勾画在肌肉注射和静脉注射丁溴东莨菪碱后均明显改善（ø 组：3.6+/-0.7；im 组：2.9+/-0.7；iv 组：2.9+/-0.7；p=0.001）。然而，直肠内线圈内的运动伪影测量值没有显著差异（ø 组：1.18+/-0.14；im 组：1.15+/-0.11；iv 组：1.12+/-0.06；p=0.39）。研究组之间前列腺、神经血管束、盆腔淋巴结的显示以及整体图像质量的定性评估也没有显著差异。
总之，丁溴东莨菪碱对图像质量的影响较小，不是前列腺 MRI 的必需条件。
