Integrated Dept. of Immunology, National Jewish Health, 1400 Jackson St., Denver, CO 80206, United States; Univ. of Colorado Denver, Aurora, CO 80045, USA.
Semin Immunol. 2010 Aug;22(4):193-8. doi: 10.1016/j.smim.2010.03.006. Epub 2010 May 6.
The gammadelta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gammadelta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gammadelta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gammadelta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus.
γδ T 淋巴细胞通常根据 TCR 成分的表达分为亚群。这种划分最初是因为发现在特定上皮组织中存在的 γδ T 细胞，其 TCR 表现出组织特异性差异。现在有许多例子表明，γδ T 细胞亚群似乎也偏向于执行特定的功能。这表明特定的 γδ TCR 类型在胸腺发育过程中指导细胞获得某种类型的功能编程。在这里，我们描述了功能不同、TCR 定义的 γδ T 细胞亚群，并证明它们的功能在胸腺中是预先确定的。
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