当归补血汤的化学成分及其对肝纤维化的抑制作用。
Chemical composition and inhibitory effect on hepatic fibrosis of Danggui Buxue Decoction.
机构信息
Department of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian 116044, PR China.
出版信息
Fitoterapia. 2010 Oct;81(7):793-8. doi: 10.1016/j.fitote.2010.04.007. Epub 2010 May 6.
The present study was carried out to investigate chemical components and therapeutic effects on hepatic fibrosis of Danggui Buxue Decoction (DBD) in rabbits. The chemical components of DBD were analyzed by LC-DAD-MS. Schistosomiasis hepatic fibrosis was employed as models of hepatic fibrosis. The rabbits were divided into treatment and control groups. DBD was orally administered at a dose of 50 g/kg rabbit's weight in treatment group. We evaluated the therapeutic effects of DBD on hepatic fibrosis in rabbits using B-ultrasound images, histopathologic examination, and hyaluronic acid content in serum. The results indicated that DBD had good therapeutic effects for hepatic fibrosis.
本研究旨在探讨当归补血汤（DBD）对兔肝纤维化的化学成分和治疗作用。采用 LC-DAD-MS 分析 DBD 的化学成分。采用血吸虫病肝纤维化作为肝纤维化模型。将兔子分为治疗组和对照组。治疗组给予 DBD 口服，剂量为 50g/kg 兔体重。我们使用 B 超图像、组织病理学检查和血清透明质酸含量评估 DBD 对兔肝纤维化的治疗作用。结果表明，DBD 对肝纤维化有良好的治疗作用。
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