慢性丙型肝炎患者唾液中丙型肝炎病毒RNA的检测结果与唾液流量或口干症无关。
Detection of HCV RNA in saliva does not correlate with salivary flow or xerostomia in patients with chronic hepatitis C.
作者信息
de Mattos Camargo Grossmann Soraya, Teixeira Rosângela, de Oliveira Guilherme Corrêa, do Carmo Maria Auxiliadora Vieira
机构信息
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):851-6. doi: 10.1016/j.tripleo.2010.02.012.
OBJECTIVE
The objective of this study was to investigate the prevalence of hepatitis C virus (HCV) RNA in saliva and its possible association with xerostomia and hyposalivation in patients with chronic hepatitis C.
STUDY DESIGN
One hundred and thirty-six patients with confirmed diagnosis of chronic hepatitis C were prospectively analyzed before HCV treatment. The prevalence of xerostomia and hyposalivation was clinically evaluated. HCV RNA was investigated in saliva samples by qualitative PCR test. Univariate and multivariate analyses were used to verify associations.
RESULTS
Xerostomia was reported by 48 (35.3%) patients, whereas hyposalivation was observed in 26 (19.1%). HCV RNA was positive in the saliva of 53 (39.0%) patients. An association among HCV RNA-positive saliva with xerostomia or hyposalivation was not observed.
CONCLUSION
Our results demonstrate that the detection of HCV in saliva does not correlate with salivary flow or xerostomia in patients with chronic hepatitis C.
目的
本研究旨在调查慢性丙型肝炎患者唾液中丙型肝炎病毒（HCV）RNA的流行情况及其与口干症和唾液分泌减少的可能关联。
研究设计
对136例确诊为慢性丙型肝炎的患者在进行HCV治疗前进行前瞻性分析。对口干症和唾液分泌减少的患病率进行临床评估。通过定性PCR检测唾液样本中的HCV RNA。采用单因素和多因素分析来验证相关性。
结果
48例（35.3%）患者报告有口干症，而26例（19.1%）观察到唾液分泌减少。53例（39.0%）患者的唾液中HCV RNA呈阳性。未观察到HCV RNA阳性唾液与口干症或唾液分泌减少之间存在关联。
结论
我们的结果表明，慢性丙型肝炎患者唾液中HCV的检测与唾液流量或口干症无关。
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