Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
Am J Obstet Gynecol. 2010 Aug;203(2):109.e1-6. doi: 10.1016/j.ajog.2010.03.018. Epub 2010 May 10.
Reports exist in which cellular leiomyomas (CLs) appear to have clinical characteristics or genetic profiles similar to leiomyosarcomas. This study aimed to determine whether most CLs differ clinically from typical uterine leiomyomas (ULs).
A case-control study was conducted with women who underwent surgical procedures between January 1989 and December 2008 and who were diagnosed with a CL (n = 99). Control subjects, who were matched in a 2:1 ratio, were women with a diagnosis of UL (n = 198). Hospital and ambulatory records were reviewed.
In multivariable logistic regression analyses, women with CLs were more likely to have surgery for the indication of enlarging leiomyoma and less likely to have concomitant endometriosis or adenomyosis. Uteri that contained CLs were also more likely to have larger and fewer leiomyomas when compared with control subjects.
CLs have a distinct clinical phenotype compared with ULs and have some characteristics in common with leiomyosarcomas.
有报道称，细胞平滑肌瘤（CL）似乎具有与平滑肌肉瘤相似的临床特征或遗传特征。本研究旨在确定大多数 CL 是否在临床上与典型的子宫平滑肌瘤（UL）不同。
本研究采用病例对照研究方法，对 1989 年 1 月至 2008 年 12 月间接受手术治疗的妇女进行了研究，这些妇女被诊断为 CL（n=99）。按照 2:1 的比例匹配对照受试者，这些对照受试者为诊断为 UL 的妇女（n=198）。对医院和门诊记录进行了回顾。
在多变量逻辑回归分析中，CL 患者更有可能因肌瘤增大而行手术治疗，而较少因同时患有子宫内膜异位症或子宫腺肌病而行手术治疗。与对照组相比，含有 CL 的子宫更有可能有更大和更少的平滑肌瘤。
CL 与 UL 具有明显不同的临床表型，并且与平滑肌肉瘤具有一些共同特征。
