The Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.
Psychoneuroendocrinology. 2012 Apr;37(4):482-90. doi: 10.1016/j.psyneuen.2011.07.016. Epub 2011 Aug 17.
Data from animal studies suggest that oxytocin is an important modulating neuropeptide in regulation of social interaction. One human study has reported a negative correlation between CSF oxytocin levels, life history of aggression and suicidal behaviour. We hypothesized that CSF oxytocin levels would be related to suicidal behaviour, suicide intent, lifetime interpersonal violence and suicide risk. 28 medication free suicide attempters and 19 healthy volunteers participated in this cross sectional and longitudinal study. CSF and plasma morning basal levels of oxytocin were assessed with specific radio-immunoassays. The Beck Suicide Intent Scale (SIS), the Freeman scale and the Karolinska Interpersonal Violence Scale (KIVS) were used to assess suicide intent and lifetime violent behaviour. All patients were followed up for cause of death. The mean follow-up was 21 years. Suicide attempters had lower CSF oxytocin levels compared to healthy volunteers p=0.077. In suicide attempters CSF oxytocin showed a significant negative correlation with the planning subscale of SIS. CSF oxytocin showed a significant negative correlation with suicide intent, the planning subscale of SIS and Freeman interruption probability in male suicide attempters. Correlations between plasma oxytocin levels and the planning subscale of SIS and Freeman interruption probability were significant in male suicide attempters. Lifetime violent behaviour showed a trend to negative correlation with CSF oxytocin. In the regression analysis suicide intent remained a significant predictor of CSF oxytocin corrected for age and gender whereas lifetime violent behaviour showed a trend to be a predictor of CSF oxytocin. Oxytocin levels did not differ significantly in suicide victims compared to survivors. CSF oxytocin may be an important modulator of suicide intent and interpersonal violence in suicide attempters.
动物研究的数据表明，催产素是调节社会互动的重要调节神经肽。一项人类研究报告称，CSF 催产素水平与攻击行为和自杀行为的生命史呈负相关。我们假设 CSF 催产素水平与自杀行为、自杀意图、终生人际暴力和自杀风险有关。28 名未服用药物的自杀未遂者和 19 名健康志愿者参与了这项横断面和纵向研究。采用特定的放射免疫测定法评估 CSF 和血浆晨基础催产素水平。使用贝克自杀意图量表（SIS）、弗里曼量表和卡罗林斯卡人际暴力量表（KIVS）评估自杀意图和终生暴力行为。所有患者都因死因进行了随访。平均随访时间为 21 年。自杀未遂者的 CSF 催产素水平明显低于健康志愿者（p=0.077）。在自杀未遂者中，CSF 催产素与 SIS 的计划分量表呈显著负相关。CSF 催产素与自杀意图、SIS 的计划分量表和男性自杀未遂者的弗里曼中断概率呈显著负相关。男性自杀未遂者的血浆催产素水平与 SIS 的计划分量表和弗里曼中断概率呈显著相关。终生暴力行为与 CSF 催产素呈负相关趋势。在回归分析中，自杀意图仍然是 CSF 催产素的一个重要预测因子，校正年龄和性别后，而终生暴力行为则显示出预测 CSF 催产素的趋势。CSF 催产素在自杀死亡者和幸存者之间没有显著差异。CSF 催产素可能是自杀未遂者自杀意图和人际暴力的重要调节剂。
