Department of Clinical Sciences, Division of Infection Medicine, Lund University, SE-22184 Lund, Sweden.
Clin Chim Acta. 2010 Sep 6;411(17-18):1172-80. doi: 10.1016/j.cca.2010.04.032. Epub 2010 May 7.
Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease.
A 组链球菌（GAS，化脓性链球菌）是一种专性人类病原体，已经被广泛研究了几十年。这些细菌引起的疾病范围从简单和浅表到严重和侵袭性感染。为了引起这些并发症，GAS 已经进化出许多表面结合和分泌的毒力因子，其中 M 蛋白可能是最具特征的。有证据表明，M 蛋白是多功能的致病决定因素，多年来已经报道了许多 M 蛋白与人类宿主之间的相互作用。本文综述旨在介绍 M 蛋白引发疾病的最重要毒力机制的最新概述。
