Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Keck School of Medicine at USC, Los Angeles, CA, USA.
Am J Obstet Gynecol. 2010 May;202(5):485.e1-9. doi: 10.1016/j.ajog.2010.01.074.
To evaluate the effect of selective estrogen receptor modulators and ethinyl estradiol on the biomechanical and biochemical properties of the uterosacral and round ligaments in the monkey model of menopause.
A randomized, double-blind, placebo-controlled study on 11 female macaque monkeys. Ovariectomized monkeys received 12 weeks of placebo, raloxifene, tamoxifen, or ethinyl estradiol. Biomechanical step-strain testing and real-time polymerase chain reaction was performed on the uterosacral and round ligaments.
Tamoxifen and raloxifene uterosacrals expressed differing collagen I/III receptor density ratios, but both selective estrogen receptor modulators showed decreased tensile stiffness compared to ethinyl estradiol and controls.
These findings support a possible effect of selective estrogen receptor modulators on biomechanical and biochemical properties of uterosacrals. This may play a role in pelvic organ prolapse.
评估选择性雌激素受体调节剂和炔雌醇对绝经后猴模型子宫骶骨和圆韧带生物力学和生化特性的影响。
对 11 只雌性猕猴进行随机、双盲、安慰剂对照研究。去卵巢的猴子接受了 12 周的安慰剂、雷洛昔芬、他莫昔芬或炔雌醇治疗。对子宫骶骨和圆韧带进行生物力学阶跃应变测试和实时聚合酶链反应。
他莫昔芬和雷洛昔芬的子宫骶骨表达不同的胶原 I/III 受体密度比，但与炔雌醇和对照组相比，两种选择性雌激素受体调节剂的拉伸刚度均降低。
这些发现支持选择性雌激素受体调节剂对子宫骶骨生物力学和生化特性的可能影响。这可能在盆腔器官脱垂中起作用。
