Vardy Michael D, Gardner Thomas R, Cosman Felicia, Scotti Richard J, Mikhail Magdy S, Preiss-Bloom A Orahn, Williams J Koudy, Cline J Mark, Lindsay Robert
Columbia College of Physicians & Surgeons, New York, NY, USA.
Am J Obstet Gynecol. 2005 May;192(5):1741-51. doi: 10.1016/j.ajog.2004.10.639.
The purpose of this study was to determine effects of ovariectomy (OVX) and conjugated equine estrogens plus medroxyprogesterone acetate (CEE/MPA), or ethinyl estradiol plus norethindrone acetate (EE/NA) on biomechanics of uterosacral (USL) and round (RL) ligaments in postmenopausal (PMP) monkeys.
This was a randomized, triple blind, placebo-controlled study. OVX monkeys received 12 months no treatment (Pbo) (n = 19), CEE/MPA (n = 19), or EE/NA (n = 21). USL and RL step strains and stress-relaxation data were curve-fitted, giving strain-dependent tensile modulus (TM) from 0% to 30%.
(1) USL: TM for both treatment groups was greater than Pbo for strains from 0% to 12% (P < .04). (2) RL: TM for both treatment groups was smaller than Pbo for strains from 12% to 30% (P < .05). No differences were found between treatment regimens.
CEE/MPA and EE/NA both affect functional biomechanical properties by increasing tensile stiffness in the USL and decreasing it in the RL.
本研究旨在确定卵巢切除术（OVX）以及结合马雌激素加醋酸甲羟孕酮（CEE/MPA）或炔雌醇加醋酸炔诺酮（EE/NA）对绝经后（PMP）猴子子宫骶骨韧带（USL）和圆韧带（RL）生物力学的影响。
这是一项随机、三盲、安慰剂对照研究。接受卵巢切除术的猴子12个月不接受治疗（Pbo）（n = 19），接受CEE/MPA治疗（n = 19），或接受EE/NA治疗（n = 21）。对子宫骶骨韧带和圆韧带的阶跃应变及应力松弛数据进行曲线拟合，得出0%至30%应变依赖性拉伸模量（TM）。
（1）子宫骶骨韧带：两个治疗组在0%至12%应变时的拉伸模量均大于安慰剂组（P < 0.04）。（2）圆韧带：两个治疗组在12%至30%应变时的拉伸模量均小于安慰剂组（P < 0.05）。各治疗方案之间未发现差异。
CEE/MPA和EE/NA均通过增加子宫骶骨韧带的拉伸刚度和降低圆韧带的拉伸刚度来影响功能生物力学特性。
