埃及城乡乳腺癌发病率的差异（1999-2006 年）。
Urban-rural differences in breast cancer incidence in Egypt (1999-2006).
机构信息
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109, USA.
出版信息
Breast. 2010 Oct;19(5):417-23. doi: 10.1016/j.breast.2010.04.005. Epub 2010 May 8.
OBJECTIVE
To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer.
METHODS
We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed.
RESULTS
Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/10(5)-year for urban areas versus 17.8/10(5)-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla.
CONCLUSIONS
Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances.
目的
描述埃及盖勒尤卜省乳腺癌发病率的城乡差异，并探讨这些差异是否可以用已知的乳腺癌危险因素来解释。
方法
我们使用埃及盖勒尤卜省基于人群的癌症登记处的数据，评估了 1999 年至 2006 年期间乳腺癌的发病率。埃及人口普查提供了特定地区的人口、年龄和城乡分类数据。分析了乳腺癌的发病模式以及按地区和年龄划分的城乡差异。
结果
总体而言，城市地区的乳腺癌发病率是农村地区的三到四倍（城市地区为 60.9/10(5)年，农村地区为 17.8/10(5)年；IRR=3.73，95%CI=3.30，4.22）。在所有年份，所有年龄组的城市地区乳腺癌发病率均持续较高。坦塔和迈哈莱等较发达地区的乳腺癌发病率也较高。
结论
城市和较发达地区乳腺癌发病率较高可能与更高的外源性雌激素暴露以及其他内分泌干扰物和遗传毒性物质有关。
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