Indian Institute of Public Health, Public Health Foundation of India, New Delhi, India.
Cancer Epidemiol. 2011 Jun;35(3):254-64. doi: 10.1016/j.canep.2010.09.010. Epub 2010 Oct 29.
We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures.
Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression.
Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR=4.85, 95% CI=3.76, 6.26) and uterus (IRR=6.05, 95% CI=4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR=29.45, 95% CI=10.63, 81.61) and uterine cancer (IRR=15.98, 95% CI=2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites.
Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.
我们研究了埃及盖勒尤卜省的癌症发病率变化，以探讨与人口统计学和环境暴露相关的地理差异。
利用盖勒尤卜省唯一的基于人群的癌症登记处的数据，我们研究了 4 年来（1999-2002 年）男性和女性的 10 种最常见癌症。人口普查数据提供了分母和城乡定义。使用泊松回归估计了粗发病率（IR）、调整发病率比（IRR）和 95%置信区间（CI）。
所有常见癌症的发病率在男性中均高于女性，在所有癌症部位，城市的发病率均高于农村。对于男性和女性，城乡发病率差异最大的是前列腺癌（IRR=4.85，95%CI=3.76，6.26）和子宫癌（IRR=6.05，95%CI=4.17，8.78）。在男性和女性中，El-Santa 区的城乡差异在区内喉癌（IRR=29.45，95%CI=10.63，81.61）和子宫癌（IRR=15.98，95%CI=2.69，95.10）中最大。El-Santa 区也是所有八个区中大多数癌症发病率最高的城市。
盖勒尤卜省的癌症存在地理差异，需要深入调查特定的环境因素，以解释该地区的地理癌症。
