前瞻性研究比较芬太尼和依托咪酯诱导麻醉时皮肤阻抗与 EEG 参数。

Prospective study comparing skin impedance with EEG parameters during the induction of anaesthesia with fentanyl and etomidate.

机构信息

University of Düsseldorf, Department of Anaesthesiology, Moorenstr.5, 40225 Düsseldorf, Germany.

出版信息

Eur J Med Res. 2010 Feb 26;15(2):47-53. doi: 10.1186/2047-783x-15-2-47.

OBJECTIVE

Sympathetic stimulation leads to a change in electrical skin impedance. So far it is unclear whether this effect can be used to measure the effects of anaesthetics during general anaesthesia. The aim of this prospective study is to determine the electrical skin impedance during induction of anaesthesia for coronary artery bypass surgery with fentanyl and etomidate.

METHODS

The electrical skin impedance was measured with the help of an electro-sympathicograph (ESG). In 47 patients scheduled for elective cardiac surgery, anaesthesia was induced with intravenous fentanyl 10 mug/kg and etomidate 0.3mg/kg. During induction, the ESG (Electrosympathicograph), BIS (Bispectral IndeX), BP (arterial blood pressure) and HR (heart rate) values of each patient were recorded every 20 seconds.The observation period from administration of fentanyl to intubation for surgery lasted 4 min. -

RESULTS

The ESG recorded significant changes in the electrical skin impedance after administration of fentanyl and etomidate(p <0.05). During induction of anaesthesia, significant changes of BIS, HR and blood pressure were observed as well (p <0.05).

CONCLUSIONS

The electrical skin impedance measurement may be used to monitor the effects of anesthetics during general anaesthesia.

目的

交感神经刺激会导致皮肤阻抗发生变化。目前尚不清楚这种效应是否可用于测量全身麻醉期间麻醉剂的效果。本前瞻性研究旨在确定芬太尼和依托咪酯诱导冠状动脉旁路手术全身麻醉期间的皮肤阻抗。

方法

使用交感神经描记器（ESG）测量皮肤阻抗。在 47 例行择期心脏手术的患者中，静脉注射芬太尼 10 mcg/kg 和依托咪酯 0.3mg/kg 诱导麻醉。诱导过程中，每位患者的 ESG（交感神经描记器）、BIS（双谱指数）、BP（动脉血压）和 HR（心率）值每 20 秒记录一次。从给予芬太尼到手术插管的观察期持续 4 分钟。