Abramson Family Cancer Institute, University of Pennsylvania, Philadelphia, 19104, USA.
Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a002501. doi: 10.1101/cshperspect.a002501. Epub 2010 Mar 17.
The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is dependent on its multiple protein interaction domains, as it creates a scaffold on which key signaling complexes are built. SLP-76 is critical for supporting signaling downstream of both immunoreceptors and integrins. The signaling molecules used both upstream and downstream of SLP-76 are similar among these receptors and across cell types; however, important differences exist. Appreciating how SLP-76 coordinates signal transduction across different cell and receptor types provides insights into the complex interplay of pathways critical for activation of cells of the immune system that are essential for host defense.
衔接蛋白 SLP-76 在包括 T 细胞、血小板和中性粒细胞在内的多种造血谱系中表达。SLP-76 介导的信号转导依赖于其多个蛋白相互作用结构域，因为它形成了一个支架，其上构建了关键的信号复合物。SLP-76 对于支持免疫受体和整合素下游的信号转导至关重要。这些受体和细胞类型之间的信号分子在 SLP-76 的上下游使用相似；然而，存在重要差异。了解 SLP-76 如何协调不同细胞和受体类型的信号转导，为理解对宿主防御至关重要的免疫系统细胞激活的关键途径的复杂相互作用提供了线索。
