The University of Tennessee Health Sciences Center, Department of Molecular Sciences, 858 Madison Avenue, Memphis, TN 38163, USA.
J Bacteriol. 2010 Jul;192(14):3829-32. doi: 10.1128/JB.00191-10. Epub 2010 May 7.
Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple Vibrio species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.
环(苯丙)是一种由多种弧菌属细菌产生的环二肽。在这项工作中,我们提供的证据表明,在 O1 型 El Tor 霍乱弧菌 N16961 菌株在毒力基因诱导条件下生长时,环(苯丙)抑制霍乱毒素(CT)和毒素调节菌毛(TCP)等毒力因子的产生。环(苯丙)对 CT 和 TCP 产生的抑制作用与毒力调节基因 tcpPH 的转录减少相关,并通过 tcpPH 的过表达得到缓解。