环二肽环（苯丙氨酸-脯氨酸）抑制 O1 型埃尔托霍乱弧菌的霍乱毒素和毒素调节菌毛的产生。
The cyclic dipeptide cyclo(Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae.
机构信息
The University of Tennessee Health Sciences Center, Department of Molecular Sciences, 858 Madison Avenue, Memphis, TN 38163, USA.
出版信息
J Bacteriol. 2010 Jul;192(14):3829-32. doi: 10.1128/JB.00191-10. Epub 2010 May 7.
Abstract
Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple Vibrio species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.
摘要
环（苯丙）是一种由多种弧菌属细菌产生的环二肽。在这项工作中，我们提供的证据表明，在 O1 型 El Tor 霍乱弧菌 N16961 菌株在毒力基因诱导条件下生长时，环（苯丙）抑制霍乱毒素（CT）和毒素调节菌毛（TCP）等毒力因子的产生。环（苯丙）对 CT 和 TCP 产生的抑制作用与毒力调节基因 tcpPH 的转录减少相关，并通过 tcpPH 的过表达得到缓解。
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The cyclic dipeptide cyclo(Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae.环二肽环（苯丙氨酸-脯氨酸）抑制 O1 型埃尔托霍乱弧菌的霍乱毒素和毒素调节菌毛的产生。
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本文引用的文献
1
Virulence regulator AphB enhances toxR transcription in Vibrio cholerae.毒力调节因子 AphB 增强霍乱弧菌中 toxR 转录。
BMC Microbiol. 2010 Jan 6;10:3. doi: 10.1186/1471-2180-10-3.
2
Effect of the efflux inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae.外排抑制剂1-(1-萘甲基)-哌嗪和苯丙氨酸-β-萘酰胺对霍乱弧菌抗菌敏感性及毒力因子产生的影响
J Antimicrob Chemother. 2009 Jan;63(1):103-8. doi: 10.1093/jac/dkn466. Epub 2008 Nov 14.
3
Vibrio cholerae RND family efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse small intestine.霍乱弧菌RND家族外排系统是抗菌耐药性、最佳毒力因子产生以及在幼鼠小肠中定殖所必需的。
Infect Immun. 2008 Aug;76(8):3595-605. doi: 10.1128/IAI.01620-07. Epub 2008 May 19.
4
Regulation of virulence in Vibrio cholerae: the ToxR regulon.霍乱弧菌毒力的调控：ToxR调控子
Future Microbiol. 2007 Jun;2(3):335-44. doi: 10.2217/17460913.2.3.335.
5
Cyclo(Phe-Pro) modulates the expression of ompU in Vibrio spp.环（苯丙氨酸-脯氨酸）调节弧菌属中ompU的表达。
J Bacteriol. 2006 Mar;188(6):2214-21. doi: 10.1128/JB.188.6.2214-2221.2006.
6
Degradation of the membrane-localized virulence activator TcpP by the YaeL protease in Vibrio cholerae.霍乱弧菌中YaeL蛋白酶对膜定位毒力激活因子TcpP的降解作用。
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16403-8. doi: 10.1073/pnas.0505818102. Epub 2005 Oct 27.
7
Crystal structure of the virulence gene activator AphA from Vibrio cholerae reveals it is a novel member of the winged helix transcription factor superfamily.霍乱弧菌毒力基因激活因子AphA的晶体结构表明它是翼状螺旋转录因子超家族的一个新成员。
J Biol Chem. 2005 Apr 8;280(14):13779-83. doi: 10.1074/jbc.M413781200. Epub 2005 Jan 12.
8
Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoter.霍乱弧菌tcpPH启动子处毒力基因调节因子AphA、AphB和cAMP-CRP的重叠结合位点。
Mol Microbiol. 2001 Jul;41(2):393-407. doi: 10.1046/j.1365-2958.2001.02518.x.
9
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Mol Microbiol. 2000 Oct;38(1):67-84. doi: 10.1046/j.1365-2958.2000.02111.x.
10
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Nature. 2000 Aug 3;406(6795):477-83. doi: 10.1038/35020000.
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