Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland, Finland.
Horm Res Paediatr. 2010;74(3):207-11. doi: 10.1159/000282113. Epub 2010 May 6.
A connection between premature adrenarche (PA) and polycystic ovary syndrome (PCOS) has been proposed. We investigated whether anti-müllerian hormone (AMH) production is increased in prepubertal girls with PA, as it is in women with PCOS and in their prepubertal daughters.
Fifty-two prepubertal girls with PA and 48 prepubertal age-matched controls were studied. Serum AMH concentrations were determined by a specific ELISA assay and correlated with baseline steroid hormone, GnRH-stimulated LH and FSH, and glucose and insulin concentrations during an oral glucose tolerance test (OGTT).
Girls with PA had lower serum AMH concentrations than their controls (2.65 vs. 3.43 ng/ml, p = 0.035). This difference between the study groups vanished when adjusted for BMI SDS score (SDS) or body fat percentage. In the entire cohort, serum AMH concentration was negatively correlated with BMI SDS (r = -0.23, p = 0.019) and androstenedione (r = -0.22, p = 0.03), but not with age, GnRH-stimulated LH or FSH, baseline or OGTT insulin concentrations. Within the control group only, there was an inverse relationship of serum AMH with DHEAS (r = -0.32, p = 0.028) concentrations.
Unlike prepubertal daughters of PCOS women, PA girls do not have abnormalities in serum AMH concentrations at prepubertal age.
已经提出了早熟性肾上腺功能初现（PA）与多囊卵巢综合征（PCOS）之间的联系。我们研究了在青春期前的具有 PA 的女孩中是否会增加抗缪勒管激素（AMH）的产生，就像在患有 PCOS 的女性及其青春期前的女儿中一样。
研究了 52 名青春期前的具有 PA 的女孩和 48 名年龄匹配的青春期前对照者。通过特定的 ELISA 测定法测定血清 AMH 浓度，并将其与基线类固醇激素，GnRH 刺激的 LH 和 FSH 以及口服葡萄糖耐量试验（OGTT）期间的葡萄糖和胰岛素浓度相关联。
具有 PA 的女孩的血清 AMH 浓度低于其对照组（2.65 与 3.43ng/ml，p = 0.035）。当按 BMI SDS 评分（SDS）或体脂百分比进行调整时，两组之间的这种差异消失了。在整个队列中，血清 AMH 浓度与 BMI SDS（r = -0.23，p = 0.019）和雄烯二酮（r = -0.22，p = 0.03）呈负相关，但与年龄，GnRH 刺激的 LH 或 FSH，基础或 OGTT 胰岛素浓度无关。仅在对照组中，血清 AMH 与 DHEAS（r = -0.32，p = 0.028）浓度呈负相关。
与 PCOS 女性的青春期前女儿不同，PA 女孩在青春期前年龄时，血清 AMH 浓度没有异常。
