Brar Preneet Cheema, Dingle Elena, Ovadia Daniela, Pivo Sarah, Prasad Veeramac, David Raphael
Division of Pediatric Endocrinology, Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
Department of Pediatrics, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
Ann Pediatr Endocrinol Metab. 2018 Dec;23(4):210-214. doi: 10.6065/apem.2018.23.4.210. Epub 2018 Dec 31.
Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5-8 years) and age and body mass index (BMI) matched controls.
Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done.
PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, P<0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49-3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups.
Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.
青春期早熟（PA）常导致多囊卵巢综合征（PCOS）。据报道，PCOS患者的抗苗勒管激素（AMH）水平较高。我们研究了患有PA的西班牙裔女孩（5至8岁）以及年龄和体重指数（BMI）匹配的对照组的雄激素谱和AMH谱。
对符合青春期早熟纳入标准的女孩的电子病历进行回顾性研究。
PA组女孩（n = 76）与对照组女孩（n = 12）在年龄（平均值±标准差）（6.7±1岁对6.2±1.3岁）和BMI（20±10kg/m²对17.8±2.7kg/m²）方面相匹配。PA组硫酸脱氢表雄酮（63.3±51.3μg/dL对29.8±17.3μg/dL，P<0.001）和睾酮水平（11.4±4.8ng/dL对8.2±2.9ng/dL，P = 0.001）显著高于对照组。PA组和对照组的AMH值（<14岁：参考范围，0.49 - 3.15ng/mL）分别为3.2±2.2ng/mL和4.6±3.2ng/mL，无差异（P = 0.4）。在PA组中，AMH与骨龄（P = 0.
