Sahmay Sezai, Guralp Onur, Senturk Levent M, Imamoglu Metehan, Kucuk Mustafa, Irez Tulay
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine Istanbul University Istanbul Turkey.
Plajyolu cad, Bizimtepe sitesi No: 49, Demircikoy, Sarıyer 34450 Istanbul Turkey.
Reprod Med Biol. 2011 Mar 5;10(2):113-120. doi: 10.1007/s12522-011-0078-5. eCollection 2011 Jun.
To evaluate the correlation between anti-müllerian hormone (AMH) and body mass index (BMI) in patients with and without polycystic ovarian syndrome (PCOS).
Serum AMH levels of 332 women in their reproductive period and below 45 years of age who were admitted to our reproductive endocrinology clinic with infertility were investigated in a cross-sectional study. Patients were divided into two groups as BMI under and equal or over 25 kg/m. Both groups were divided into two subgroups as PCOS and non-PCOS. AMH levels of patients were analyzed for each group.
Mean AMH values of BMI <25 and ≥25 kg/m groups were 3.87 ± 2.95 and 3.58 ± 2.93 ng/mL, respectively ( > 0.05) in all patients. Means of AMH were not significantly different in BMI quartiles ( = -0.008401, = 0.96). Among 107 patients with PCOS, means of AMH were 6.85 ± 2.95 ng/mL in 56 patients with BMI <25 kg/m and 6.66 ± 3.18 ng/mL in 51 patients with BMI ≥25 kg/m ( > 0.05). In the group of 225 non-PCOS patients, means of AMH were 2.27 ± 1.12 ng/mL in 104 patients with BMI <25 kg/m and 2.28 ± 1.49 ng/mL in 121 patients with BMI ≥25 kg/m ( > 0.05).
Body mass index does not seem to have an effect on serum AMH levels in reproductive age women both with and without PCOS.
评估多囊卵巢综合征（PCOS）患者及非PCOS患者中抗苗勒管激素（AMH）与体重指数（BMI）之间的相关性。
在一项横断面研究中，对我院生殖内分泌门诊收治的332例年龄在45岁及以下的育龄期不孕女性的血清AMH水平进行了调查。患者按BMI分为<25 kg/m及≥25 kg/m两组。两组又各分为PCOS和非PCOS两个亚组。对每组患者的AMH水平进行分析。
所有患者中，BMI<25 kg/m组和≥25 kg/m组的平均AMH值分别为3.87±2.95和3.58±2.93 ng/mL（P>0.05）。AMH均值在BMI四分位数间无显著差异（P=-0.008401，P=0.96）。107例PCOS患者中，56例BMI<25 kg/m患者的AMH均值为6.85±2.95 ng/mL，51例BMI≥25 kg/m患者的AMH均值为6.66±3.18 ng/mL（P>0.05）。在225例非PCOS患者组中，104例BMI<25 kg/m患者的AMH均值为2.27±1.12 ng/mL，121例BMI≥25 kg/m患者的AMH均值为2.28±1.49 ng/mL（P>0.05）。
体重指数似乎对有或无PCOS的育龄期女性血清AMH水平均无影响。
