Luo Shunwen, Lu Yiping, Wang Feng, Xie Zhiyuan, Huang Xiaoke, Dong Qiang, Zhang Sixiao
Urological Department, West China Hospital, Sichuan University, Chengdu, China.
Urol Int. 2010;85(2):204-8. doi: 10.1159/000314528. Epub 2010 May 6.
Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner. It has been postulated to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function.
To investigate the relationship between the C-759T and G-697C polymorphisms of the 5-HT(2C) receptor and LPE.
A prospective study was conducted in 106 Han Chinese men with LPE, characterized by IELT of less than 1 min, and 84 healthy controls with IELT of more than 3 min. All subjects were genotyped for the C-759T and G-697C polymorphisms located in the promoter region of the 5-HT(2C) receptor. The frequencies of genotypes and single nucleotide mutations were compared between the two groups.
Three genotypes were detected both in the men with LPE and in the control group: -759C/-697G, -759T/-697C, and -759C/ -697C. Genotype -759T/-697G was not detected. The frequency of genotype -759T/-697C was higher in patients with LPE than in the control group (30.2 vs. 11.9%, p < 0.05), whereas the frequency of genotype -759C/-697G was lower in patients with LPE than in the control group (66.0 vs. 83.3%, p < 0.05). No difference was found for genotype -759C/ -697C between the two groups. Mutations at -759T and -697C were more frequent in patients than in the control group (-759T: 30.2 vs. 13.3%, p < 0.05; -697C: 30.4 vs. 16.7%, p < 0.05, respectively).
Our findings indicated that polymorphisms in the 5-HT(2C) receptor gene are associated with LPE, and men who carry the -759T or -697C genotype have increased odds of premature ejaculation. Further investigation in this field is necessary.
终生早泄（LPE）的特征是阴道内射精潜伏期（IELT）持续短于患者或其伴侣可接受的时间。据推测，它是一种具有遗传易感性的神经生物学功能障碍，与中枢5-羟色胺（5-羟色胺，5-HT）神经传递和5-HT受体功能紊乱有关。
研究5-HT（2C）受体的C-759T和G-697C多态性与LPE之间的关系。
对106名IELT小于1分钟的汉族LPE男性和84名IELT大于3分钟的健康对照者进行了一项前瞻性研究。对所有受试者进行了位于5-HT（2C）受体启动子区域的C-759T和G-697C多态性基因分型。比较了两组之间的基因型和单核苷酸突变频率。
LPE男性和对照组均检测到三种基因型：-759C/-697G、-759T/-@00C和-759C/-697C。未检测到基因型-759T/-697G。LPE患者中基因型-759T/-697C的频率高于对照组（30.2%对11.9%，p<0.05），而LPE患者中基因型-759C/-697G的频率低于对照组（66.0%对83.3%，p<0.05）。两组之间基因型-759C/-697C无差异。患者中-759T和-697C的突变频率高于对照组（-759T：30.2%对13.3%，p<0.05；-697C：30.4%对16.7%，p<0.05）。
我们的研究结果表明，5-HT（2C）受体基因多态性与LPE有关，携带-759T或-697C基因型的男性早泄几率增加。该领域有必要进行进一步研究。
