Janssen Paddy K C, van Schaik R, Zwinderman Aeilko H, Olivier Berend, Waldinger Marcel D
Division Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands; Department of Central Hospital Pharmacy, Viecuri Hospital Venlo, Venlo, The Netherlands.
Department of Clinical Chemistry (AKC), Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands.
Pharmacol Biochem Behav. 2014 Jun;121:184-8. doi: 10.1016/j.pbb.2014.01.004. Epub 2014 Jan 15.
Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 min, and has been postulated as a neurobiological dysfunction related to diminished serotonergic neurotransmission with 5-HT₁A receptor hyperfunction and 5-HT₂C hypofunction.
To investigate the relationship between 5-HT₁A receptor gene (HTR₁A)-C(1019)G promoter polymorphism and IELT in men with LPE. This polymorphism is known to increase 5-HT1A receptor expression.
A prospective study was conducted in 54 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-month period. All men were genotyped for HTR₁A gene polymorphism. Allele frequencies and genotypes of C and G variants of HTR₁A polymorphism were determined. Association between CC, CG, and GG genotypes and the IELT in men with LPE were investigated.
IELT measured by stopwatch, HTR₁A polymorphism.
In this cohort of men with LPE, the geometric mean IELT was 23.8 s. Of the 54 men, the CC, CG and GG genotype frequency for the C(1019)G polymorphism of the 5-HT₁A gene was 33%, 43% and 24%, respectively. The geometric mean IELT for the CC, CG and GG genotypes were 14.5, 27.7 and 36.0 s, respectively (p=0.019). Compared to GG and CG genotypes, men with CC genotype had a 250% and 190% shorter ejaculation time, respectively.
HTR₁A gene polymorphism is associated with the IELT in men with LPE. Men with CC genotype have shorter IELTs than men with GG and CG genotypes.
终身早泄（LPE）的特征是阴道内射精潜伏期（IELT）持续小于1分钟，并且被假定为一种神经生物学功能障碍，与5-羟色胺能神经传递减少、5-HT₁A受体功能亢进和5-HT₂C功能减退有关。
研究5-HT₁A受体基因（HTR₁A）-C(1019)G启动子多态性与LPE男性的IELT之间的关系。已知这种多态性会增加5-HT1A受体表达。
对54名荷兰白种LPE男性进行了一项前瞻性研究。在1个月的时间内，通过秒表评估性交时的基线IELT。对所有男性进行HTR₁A基因多态性基因分型。确定HTR₁A多态性的C和G变体的等位基因频率和基因型。研究LPE男性中CC、CG和GG基因型与IELT之间的关联。
通过秒表测量的IELT，HTR₁A多态性。
在这个LPE男性队列中，几何平均IELT为23.8秒。在54名男性中，5-HT₁A基因C(1019)G多态性的CC、CG和GG基因型频率分别为33%、43%和24%。CC、CG和GG基因型的几何平均IELT分别为14.5、27.7和36.0秒（p=0.019）。与GG和CG基因型相比，CC基因型的男性射精时间分别短250%和190%。
HTR₁A基因多态性与LPE男性的IELT相关。CC基因型的男性IELT比GG和CG基因型的男性短。
