Hoekman P, van de Perre P, Nelissen J, Kwisanga B, Bogaerts J, Kanyangabo F
Department of Orthopedics and Traumatology, Centre Hospitalier de Kigali, Rwanda.
J Bone Joint Surg Am. 1991 Jun;73(5):675-9.
In a prospective study of 214 patients who had elective extensive operations for fractures, we compared the relative frequencies of postoperative infections in the seventeen patients who were seropositive for human immunodeficiency virus and had associated clinical symptoms, in the twenty-six patients who were seropositive and had no associated clinical symptoms, and in the 171 patients who were seronegative. The relative frequency of postoperative infection was significantly higher in patients who were seropositive and had associated clinical symptoms (four of seventeen) than in patients who were seronegative (eight of 171) (Fisher exact test, p = 0.01). In all patients who were seropositive and had a postoperative bacterial infection, treatment with antibiotics was effective. The results of this study suggest that people who are seropositive for human immunodeficiency virus and have associated symptoms are at increased risk for postoperative infection.
在一项针对214例因骨折接受择期大手术患者的前瞻性研究中，我们比较了17例人类免疫缺陷病毒血清学阳性且伴有临床症状的患者、26例血清学阳性但无相关临床症状的患者以及171例血清学阴性患者术后感染的相对频率。血清学阳性且伴有临床症状的患者（17例中有4例）术后感染的相对频率显著高于血清学阴性患者（171例中有8例）（Fisher精确检验，p = 0.01）。在所有血清学阳性且发生术后细菌感染的患者中，抗生素治疗有效。本研究结果表明，人类免疫缺陷病毒血清学阳性且有相关症状的人群术后感染风险增加。
