Paiement G D, Hymes R A, LaDouceur M S, Gosselin R A, Green H D
Department of Orthopedic Surgery University of California, San Francisco General Hospital 94110.
J Trauma. 1994 Oct;37(4):545-50; discussion 550-1. doi: 10.1097/00005373-199410000-00005.
In a retrospective study of 476 surgical orthopedic trauma patients, we compared postoperative infection rates between individuals seropositive for the human immunodeficiency virus (HIV) and with no associated clinical symptoms with HIV-seronegative patients. Overall, the surgical postoperative infection rate was 16.7% in seropositive patients and 5.4% in the seronegative group (Chi-square, p = 0.035). When open fractures were considered separately, the seropositive group had a 55.6% infection rate compared with 11.3% in the seronegative group (Fisher's exact test, p = 0.004). Similarly, seropositive patients also had significantly increased rates of postoperative non-wound infections and complications (Chi-square p < 0.001). Asymptomatic HIV-seropositive orthopedic trauma patients are at significantly higher risk for postoperative infections than their seronegative counterparts. For HIV-seropositive patients with open fractures, this risk is especially pronounced.
在一项针对476例外科骨科创伤患者的回顾性研究中，我们比较了人类免疫缺陷病毒（HIV）血清阳性且无相关临床症状的个体与HIV血清阴性患者的术后感染率。总体而言，血清阳性患者的外科术后感染率为16.7%，血清阴性组为5.4%（卡方检验，p = 0.035）。当单独考虑开放性骨折时，血清阳性组的感染率为55.6%，而血清阴性组为11.3%（Fisher精确检验，p = 0.004）。同样，血清阳性患者术后非伤口感染和并发症的发生率也显著增加（卡方检验，p < 0.001）。无症状的HIV血清阳性骨科创伤患者术后感染的风险明显高于血清阴性患者。对于开放性骨折的HIV血清阳性患者，这种风险尤为明显。
