Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong.
Mediators Inflamm. 2010;2010:495416. doi: 10.1155/2010/495416. Epub 2010 May 5.
Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD.
脂肪组织是与腹膜透析（PD）相关的慢性炎症的主要部位，常使腹膜炎复杂化。肥胖相关炎症在接受维持性 PD 的患者的慢性炎症发展中起着重要的促成作用。然而，这种联系的分子和细胞机制尚不确定。脂肪组织合成不同的脂肪因子和细胞因子，在局部和全身调节炎症、胰岛素作用和葡萄糖代谢。相反，炎症会阻碍脂肪细胞的分化，并进一步加剧脂肪组织功能障碍和炎症。了解脂肪组织在 PD 期间的炎症作用以及间皮损伤的愈合机制将有助于设计新的治疗方法来减缓腹膜透析过程中腹膜损伤的进展。本文综述了腹膜脂肪组织在 PD 下慢性腹膜炎症和 PD 期间浆膜修复中的作用。
