Department of Internal Medicine, Division of Nephrology, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, Kaohsiung, Taiwan.
Artif Organs. 2010 Jul;34(7):E222-9. doi: 10.1111/j.1525-1594.2010.01000.x. Epub 2010 Jun 10.
Chronic inflammation is a well-recognized complication in dialysis patients and a potential role of the adipose tissue as an important tissue of origin contributing to inflammation has been proposed. Stable peritoneal dialysis (PD) patients were enrolled to investigate the relationship between serum levels of proinflammatory cytokines and adipokines. Our results revealed that there was a strong association between high sensitivity C-reactive protein and interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) but not with IL-10 and IL-18. IL-6 correlated with TNF-alpha, IL-10, and IL-18. No association was found between IL-10 and IL-18. Adiponectin was positively correlated with all proinflammatory cytokines, except IL-10. No significant association was found between resistin and proinflammatory cytokines. Hepatocyte growth factor (HGF) was directly related to proinflammatory cytokines but not with adipokines. The presence of residual kidney function (RKF) affected IL-6, TNF-alpha, and HGF levels. The peritoneal transport property did not influence inflammatory cytokine and adipokine levels. In conclusion, there was a close relationship between proinflammatory cytokines and adipokines. HGF correlated with proinflammatory cytokines but not with adipokines. The PD-related factors such as RKF, peritoneal property and dialysis glucose load affected levels of proinflammatory cytokines. Body mass index was an important determinant of leptin and adiponectin in PD patients.
慢性炎症是透析患者的一种公认并发症，脂肪组织作为炎症的重要来源之一的潜在作用已被提出。本研究纳入稳定的腹膜透析（PD）患者，旨在研究促炎细胞因子和脂肪因子与血清水平之间的关系。我们的结果表明，高敏 C 反应蛋白与白细胞介素（IL）-6 和肿瘤坏死因子-α（TNF-α）之间存在强烈关联，但与 IL-10 和 IL-18 之间无关联。IL-6 与 TNF-α、IL-10 和 IL-18 相关。IL-10 与 IL-18 之间无关联。脂联素与所有促炎细胞因子呈正相关，除了 IL-10。抵抗素与促炎细胞因子之间无显著关联。肝细胞生长因子（HGF）与促炎细胞因子直接相关，但与脂肪因子无关。残余肾功能（RKF）的存在影响 IL-6、TNF-α 和 HGF 水平。腹膜转运特性不影响促炎细胞因子和脂肪因子水平。总之，促炎细胞因子和脂肪因子之间存在密切关系。HGF 与促炎细胞因子相关，但与脂肪因子无关。RKF、腹膜特性和透析葡萄糖负荷等 PD 相关因素影响促炎细胞因子水平。体重指数是 PD 患者瘦素和脂联素的重要决定因素。
