脂肪微环境对卵巢癌进展的调节作用

Chehade Hussein, Tedja Roslyn, Ramos Harry, Bawa Tejeshwar Singh, Adzibolosu Nicholas, Gogoi Radhika, Mor Gil, Alvero Ayesha B

C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.

Karmanos Cancer Institute, Detroit, MI 48201, USA.

Cancers (Basel). 2022 May 1;14(9):2267. doi: 10.3390/cancers14092267.

The tumor microenvironment of ovarian cancer is the peritoneal cavity wherein adipose tissue is a major component. The role of the adipose tissue in support of ovarian cancer progression has been elucidated in several studies from the past decades. The adipocytes, in particular, are a major source of factors, which regulate all facets of ovarian cancer progression such as acquisition of chemoresistance, enhanced metastatic potential, and metabolic reprogramming. In this review, we summarize the relevant studies, which highlight the role of adipocytes in ovarian cancer progression and offer insights into unanswered questions and possible future directions of research.

卵巢癌的肿瘤微环境是腹腔，其中脂肪组织是主要成分。在过去几十年的多项研究中，已经阐明了脂肪组织在支持卵巢癌进展中的作用。特别是脂肪细胞是各种因子的主要来源，这些因子调节卵巢癌进展的各个方面，如获得化疗耐药性、增强转移潜能和代谢重编程。在这篇综述中，我们总结了相关研究，这些研究突出了脂肪细胞在卵巢癌进展中的作用，并对未解决的问题和未来可能的研究方向提供了见解。