Seki Hiroyuki, Sasaki Takaharu, Ueda Tomomi, Arita Makoto
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
ScientificWorldJournal. 2010 May 4;10:818-31. doi: 10.1100/tsw.2010.72.
Inflammation is the first response of the immune system to infection or injury, but excessive or inappropriate inflammatory responses contribute to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of ù-3 polyunsaturated fatty acids (i.e., eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) indicate that they have beneficial impact on these diseases, although the mechanisms are poorly understood at the molecular level. In this decade, it has been revealed that EPA and DHA are enzymatically converted to bioactive metabolites in the course of acute inflammation and resolution. These metabolites were shown to regulate immune cell functions and to display potent anti-inflammatory actions both in vitro and in vivo. Because of their ability to resolve an acute inflammatory response, they are referred to as proresolving mediators, or resolvins. In this review, we provide an overview of the formation and actions of these lipid mediators.
炎症是免疫系统对感染或损伤的首要反应，但过度或不适当的炎症反应会导致一系列急慢性人类疾病。对ω-3多不饱和脂肪酸（即二十碳五烯酸[EPA]和二十二碳六烯酸[DHA]）膳食补充剂的临床评估表明，它们对这些疾病具有有益影响，尽管在分子水平上其作用机制尚不清楚。在这十年中，已发现EPA和DHA在急性炎症和炎症消退过程中可酶促转化为生物活性代谢物。这些代谢物在体外和体内均显示出调节免疫细胞功能并具有强大的抗炎作用。由于它们能够解决急性炎症反应，因此被称为促消退介质或消退素。在本综述中，我们概述了这些脂质介质的形成和作用。
