Department of Pharmaceutics, Virginia Commonwealth University, 410 N. 12th St., P.O. Box 980533, Richmond, Virginia 23298-0533, USA.
Pharm Res. 2010 Sep;27(9):1800-11. doi: 10.1007/s11095-010-0165-z. Epub 2010 May 8.
The objective of this study is to evaluate the effects of enhanced condensational growth (ECG), as a novel inhalation drug delivery method, on nano-aerosol deposition in a mouth-throat (MT) and upper tracheobronchial (TB) model using in vitro experiments and computational fluid dynamics (CFD) simulations.
Separate streams of nebulized nano-aerosols and saturated humidified air (39 degrees C-ECG; 25 degrees C-control) were combined as they were introduced into a realistic MT-TB geometry. Aerosol deposition was determined in the MT, generations G0-G2 (trachea-lobar bronchi) and G3-G5 and compared to CFD simulations.
Using ECG conditions, deposition of 560 and 900 nm aerosols was low in the MT region of the MT-TB model. Aerosol drug deposition in the G0-G2 and G3-G5 regions increased due to enhanced condensational growth compared to control. CFD-predicted depositions were generally in good agreement with the experimental values.
The ECG platform appears to offer an effective method of delivering nano-aerosols through the extrathoracic region, with minimal deposition, to the tracheobronchial airways and beyond. Aerosol deposition is then facilitated as enhanced condensational growth increases particle size. Future studies will investigate the effects of physio-chemical drug properties and realistic inhalation profiles on ECG growth characteristics.
本研究旨在评估增强冷凝生长（ECG）作为一种新型吸入药物输送方法对体外实验和计算流体动力学（CFD）模拟中口腔-咽喉（MT）和上气管支气管（TB）模型中纳米气溶胶沉积的影响。
将雾化的纳米气溶胶和饱和加湿空气（39°C-ECG；25°C-对照）的单独流在引入真实 MT-TB 几何形状时混合。在 MT、G0-G2（气管-叶支气管）和 G3-G5 级中确定气溶胶沉积，并与 CFD 模拟进行比较。
在 ECG 条件下，MT-TB 模型的 MT 区域中 560nm 和 900nm 气溶胶的沉积量较低。与对照相比，由于增强的冷凝生长，G0-G2 和 G3-G5 区域中的气溶胶药物沉积增加。CFD 预测的沉积量通常与实验值吻合良好。
ECG 平台似乎提供了一种有效的方法，可将纳米气溶胶通过胸外区域输送，沉积量最小，输送到气管支气管气道及更远的部位。然后，随着增强的冷凝生长增加颗粒大小，促进了气溶胶沉积。未来的研究将调查生理化学药物特性和现实吸入概况对 ECG 生长特性的影响。
