Department of Clinical Biochemistry, Medical School, University of Athens, Attikon General University Hospital, Athens, Greece.
Cancer Causes Control. 2010 Sep;21(9):1451-9. doi: 10.1007/s10552-010-9573-y. Epub 2010 May 8.
Leptin and adiponectin are two well-studied adipokines in relation to malignancies. In this study, we examined the association between leptin/adiponectin and risk of B-cell chronic lymphocytic leukemia (B-CLL), as well as the relationships between adipokines and several established prognostic factors of B-CLL.
Ninety-five patients with incident B-CLL and 95 hospital controls matched on age and gender were studied between 2001 and 2007, and blood samples were collected. Leptin, total and high molecular weight adiponectin, and prognostic markers of B-CLL were determined.
Cases had a higher body mass index (BMI) than controls (p = 0.01) and lower levels of leptin (p < 0.01). Significantly more cases than controls presented a family history of lymphohematopoietic cancer (LHC) (p = 0.01). Higher serum leptin levels were associated with lower risk of B-CLL adjusting for age, gender, family history of LHC, BMI and serum adiponectin; the multivariate odds ratio comparing highest to lowest tertile was 0.05 (95% CI 0.01-0.29, p trend < 0.001); Adiponectin was not significantly different between cases and controls.
Leptin was found to be inversely associated with risk of CLL but in contrast to prior studies of CLL and hematologic malignancies, this study found no significant association between CLL and adiponectin.
瘦素和脂联素是两种与恶性肿瘤密切相关的研究充分的脂肪因子。在这项研究中，我们研究了瘦素/脂联素与 B 细胞慢性淋巴细胞白血病（B-CLL）风险之间的关系，以及脂肪因子与 B-CLL 的几个已确立的预后因素之间的关系。
在 2001 年至 2007 年间，研究了 95 例新发 B-CLL 患者和 95 例年龄和性别匹配的医院对照者，并采集了血样。测定了瘦素、总和高分子量脂联素以及 B-CLL 的预后标志物。
与对照组相比，病例组的体重指数（BMI）更高（p=0.01），瘦素水平更低（p<0.01）。与对照组相比，更多的病例组存在淋巴造血系统恶性肿瘤（LHC）家族史（p=0.01）。在校正年龄、性别、LHC 家族史、BMI 和血清脂联素后，较高的血清瘦素水平与 B-CLL 风险降低相关；最高与最低三分位组的多变量比值比为 0.05（95%CI 0.01-0.29，p 趋势<0.001）；病例组和对照组之间的脂联素没有显著差异。
本研究发现瘦素与 CLL 风险呈负相关，但与 CLL 和血液恶性肿瘤的先前研究相反，本研究未发现 CLL 与脂联素之间存在显著关联。
