Division of Community Health Sciences, St George's University of London, Cranmer Terrace, London SW17 ORE, UK.
Diabetologia. 2010 Aug;53(8):1620-30. doi: 10.1007/s00125-010-1781-1. Epub 2010 May 9.
AIMS/HYPOTHESIS: Physical inactivity is implicated in unfavourable patterns of obesity and cardiometabolic risk in childhood. However, few studies have quantified these associations using objective physical activity measurements in children from different ethnic groups. We examined these associations in UK children of South Asian, black African-Caribbean and white European origin.
This was a cross-sectional study of 2,049 primary school children in three UK cities, who had standardised anthropometric measurements, provided fasting blood samples and wore activity monitors for up to 7 days. Data were analysed using multilevel linear regression and allowing for measurement error.
Overall physical activity levels showed strong inverse graded associations with adiposity markers (particularly sum of skinfold thicknesses), fasting insulin, HOMA insulin resistance, triacylglycerol and C-reactive protein; for an increase of 100 counts of physical activity per min of registered time, levels of these factors were 12.2% (95% CI 10.2-14.1%), 10.2% (95% CI 7.5-12.8%), 10.2% (95% CI 7.5-12.8%), 5.8% (95% CI 4.0-7.5%) and 19.2% (95% CI 13.9-24.2%) lower, respectively. Similar increments in physical activity levels were associated with lower diastolic blood pressure (1.0 mmHg, 95% CI 0.6-1.5 mmHg) and LDL-cholesterol (0.04 mmol/l, 95% CI 0.01-0.07 mmol/l), and higher HDL-cholesterol (0.02 mmol/l, 95% CI 0.01-0.04 mmol/l). Moreover, associations were broadly similar in strength in all ethnic groups. All associations between physical activity and cardiometabolic risk factors were reduced (albeit variably) after adjustment for adiposity.
CONCLUSIONS/INTERPRETATION: Objectively measured physical activity correlates at least as well with obesity and cardiometabolic risk factors in South Asian and African-Caribbean children as in white European children, suggesting that efforts to increase activity levels in such groups would have equally beneficial effects.
目的/假设：身体活动不足与儿童肥胖和心血管代谢风险的不良模式有关。然而，很少有研究使用来自不同种族群体的儿童的客观身体活动测量来量化这些关联。我们在英国南亚、非裔加勒比和白种欧洲血统的儿童中检查了这些关联。
这是一项在英国三个城市的 2049 名小学生中进行的横断面研究，他们进行了标准化的人体测量学测量，提供了空腹血样，并佩戴活动监测器长达 7 天。使用多级线性回归进行数据分析，并允许测量误差。
总体身体活动水平与肥胖标志物（特别是皮褶厚度总和）、空腹胰岛素、HOMA 胰岛素抵抗、三酰甘油和 C 反应蛋白呈强烈的反向梯度关联；每增加 100 次记录时间的身体活动，这些因素的水平分别降低 12.2%（95%CI 10.2-14.1%）、10.2%（95%CI 7.5-12.8%）、10.2%（95%CI 7.5-12.8%）、5.8%（95%CI 4.0-7.5%）和 19.2%（95%CI 13.9-24.2%）。身体活动水平的类似增加与舒张压降低（1.0mmHg，95%CI 0.6-1.5mmHg）和 LDL 胆固醇降低（0.04mmol/L，95%CI 0.01-0.07mmol/L）以及 HDL 胆固醇升高（0.02mmol/L，95%CI 0.01-0.04mmol/L）有关。此外，在所有种族群体中，这些关联的强度大致相似。在调整肥胖后，身体活动与心血管代谢危险因素之间的所有关联都有所减弱（尽管有所不同）。
结论/解释：客观测量的身体活动与南亚和非裔加勒比儿童的肥胖和心血管代谢危险因素的相关性至少与白种欧洲儿童一样好，这表明在这些群体中增加活动水平的努力将产生同样有益的效果。
