Leahy M B, Pippard M J, Salzmann M B, Rinsler M G, Hesp R, Smith T
Section of Haematology, MRC Clinical Research Centre, Harrow Middlesex.
J Clin Pathol. 1991 May;44(5):391-4. doi: 10.1136/jcp.44.5.391.
Blood loss in faeces was assessed by three different methods in five patients with recurrent iron deficiency. In short term (12 day) studies chemical analysis of complete stool collections for haemderived porphyrins (HemoQuant) gave results closely correlated with those obtained by measuring stool loss of 51Cr-labelled red blood cells. Whole body counting for 59Fe was relatively insensitive to small blood losses but allowed losses to be followed up over longer periods. Chemical analysis of faecal porphyrins thus provides a satisfactory alternative to radioisotopic techniques in short term quantitation of faecal blood loss, while longer term whole body counting of 59Fe may still be appropriate in a few patients for the detection and quantification of intermittent blood losses.
采用三种不同方法对5例复发性缺铁患者的粪便失血情况进行了评估。在短期（12天）研究中，对完整粪便样本进行血源性卟啉化学分析（血卟啉定量法）所得结果，与通过测定51Cr标记红细胞的粪便损失量获得的结果密切相关。全身59Fe计数对少量失血相对不敏感，但可对较长时间内的失血情况进行跟踪。因此，粪便卟啉化学分析在短期定量粪便失血方面，为放射性同位素技术提供了令人满意的替代方法，而对于少数患者，长期全身59Fe计数可能仍适用于间歇性失血的检测和定量。
