Sinha Rajiv, Marks Stephen D
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Pediatr Transplant. 2010 Aug;14(5):583-8. doi: 10.1111/j.1399-3046.2010.01334.x. Epub 2010 Apr 23.
PRT is the preferred modality for renal replacement therapy in children. Despite this, there are no studies CKD parameters as per K/DOQI criteria between PRT and NPRT in children. This was a single-centre cross-sectional study of RTR with at least one yr of post-transplant follow-up. CKD parameters as per K/DOQI were compared between PRT and NPRT. Thirty percent (39/129) of our study population was PRT. Despite similar baseline characteristics at the time of transplantation and similar post-transplantation follow-up period, a significantly lower proportion of PRT (1, 2%) were in Stage 4 CKD in contrast to NPRT (14, 16%); p = 0.03. This was also reflected in better CKD parameters among PRT with significantly lower incidences of hypertension and acidosis (p = 0.02). CKD medications were also more commonly prescribed in NPRT (p = 0.002). We demonstrated improved CKD parameters and lower use of CKD medications among PRT when compared with NPRT. This finding should act as an added impetus for PRT programmes.
腹膜透析（PRT）是儿童肾脏替代治疗的首选方式。尽管如此，尚无关于儿童PRT与非PRT（NPRT）之间按照美国肾脏病基金会肾脏病预后质量倡议（K/DOQI）标准的慢性肾脏病（CKD）参数的研究。这是一项针对肾移植受者（RTR）的单中心横断面研究，移植后随访至少1年。比较了PRT和NPRT之间按照K/DOQI标准的CKD参数。我们研究人群中有30%（39/129）采用PRT。尽管移植时基线特征相似且移植后随访期相似，但与NPRT（14.16%）相比，处于CKD 4期的PRT比例显著更低（1.2%）；p = 0.03。这也反映在PRT中更好的CKD参数上，高血压和酸中毒的发生率显著更低（p = 0.02）。NPRT中也更常开具CKD药物（p = 0.002）。与NPRT相比，我们证明了PRT中CKD参数得到改善且CKD药物使用减少。这一发现应为PRT项目提供额外的推动力。
