Johansson O, Ljungberg A, Han S W, Vaalasti A
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
J Invest Dermatol. 1991 Jun;96(6):852-6. doi: 10.1111/1523-1747.ep12475161.
gamma-melanocyte stimulating hormone (gamma-MSH)-like immunoreactivity has been found by indirect immunofluorescence in nerve fibers and terminals as well as in neutrophilic granulocytes of normal human skin. A preferential localization to sensory nerves was seen; abundant nerve fibers displaying gamma-MSH immunoreactivity were observed as free nerve endings in the basal layer of the epidermis and in the upper dermis, close to the Merkel cells, in Meissner's corpuscles, around the external root sheath of the lower part of the hair follicles, and in nerve bundles of the deeper parts of the dermis. Very few fibers were seen to be associated with sweat glands and most blood vessels, although arterioles were densely innervated. Thus, gamma-MSH should be considered for possible role as a sensory or axon-reflex chemical messenger. Furthermore, the presence of gamma-MSH in neutrophilic granulocytes raises the possibility that gamma-MSH may play a role in the genesis of post-inflammatory hyperpigmentation, nevi, and melanomas.
通过间接免疫荧光法在正常人皮肤的神经纤维、神经末梢以及嗜中性粒细胞中发现了γ-促黑素细胞激素（γ-MSH）样免疫反应性。观察到其在感觉神经中存在优先定位；在表皮基底层和上真皮层中，靠近默克尔细胞处、在梅斯纳小体中、在毛囊下部外根鞘周围以及真皮深层的神经束中，可观察到大量显示γ-MSH免疫反应性的神经纤维以游离神经末梢的形式存在。虽然小动脉有密集的神经支配，但与汗腺和大多数血管相关的纤维很少。因此，应考虑γ-MSH可能作为感觉或轴突反射化学信使发挥作用。此外，嗜中性粒细胞中存在γ-MSH增加了γ-MSH可能在炎症后色素沉着、痣和黑色素瘤的发生中起作用的可能性。
