Johansson O, Liu P Y
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Exp Dermatol. 1993 Oct;2(5):204-8. doi: 10.1111/j.1600-0625.1993.tb00034.x.
Using the indirect immunohistochemical approach, the occurrence of gamma-melanocyte stimulating hormone (gamma-MSH)-like immunoreactivity in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum, also around the orifices of cutaneous accessory organs, such as sweat glands and sebaceous glands/hair follicles. Combining these data with our previous investigations, the results support the possibility that locally produced gamma-MSH could be involved in cutaneous immune response, pigmentation and epithelial proliferation, as well as neuromodulation.
采用间接免疫组织化学方法，描述了人正常角质形成细胞中γ-促黑素（γ-MSH）样免疫反应性的发生情况。在表皮的各层（除角质层外）均观察到阳性细胞，且在棘层水平，常在皮肤附属器如汗腺和皮脂腺/毛囊的开口周围也观察到阳性细胞。将这些数据与我们之前的研究相结合，结果支持局部产生的γ-MSH可能参与皮肤免疫反应、色素沉着、上皮增殖以及神经调节的可能性。
