Institute of Psychiatry, Section Vinderen, University of Oslo, Oslo, Norway.
Psychiatry Res. 2010 May 30;182(2):123-33. doi: 10.1016/j.pscychresns.2010.01.001. Epub 2010 Apr 24.
Relationships between prefrontal and temporal lobe grey matter volumes as assessed by magnetic resonance imaging and neurocognitive test results have been reported in schizophrenia. This investigation aimed to localize brain regions where cortical thickness and neurocognitive performance were related, and investigate if such relationships might differ in schizophrenia patients and healthy controls. Sixty-seven patients with schizophrenia and 69 healthy controls were characterized by neurocognitive testing and by brain cortical thickness maps. Putative cortical thickness/cognitive score relationships were investigated with contrast analyses of general linear models for the combined sample. Regions in which relationships were present were further investigated for diagnostic interaction. In the combined sample, significant positive relationships were found between frontal, temporal and occipital regions and tests for verbal IQ, verbal learning and executive functions. Diagnostic interaction was found for the relationships between verbal IQ and the right temporo-occipital junction and the left middle occipital gyrus. In conclusion, the significant relationships between cortical thickness and neurocognitive performances were localized in brain areas known to be involved in cognition. The relationships were similar in patients and controls, except for the right temporo-occipital and left occipital cortical areas, indicating a disrupted structure-function relationship in patients with schizophrenia compared to healthy control subjects.
磁共振成像评估的前额叶和颞叶灰质体积与神经认知测试结果之间的关系在精神分裂症中已有报道。本研究旨在定位皮质厚度和神经认知表现相关的脑区，并探讨这些关系在精神分裂症患者和健康对照组中是否存在差异。对 67 名精神分裂症患者和 69 名健康对照组进行了神经认知测试和大脑皮质厚度图分析。通过对合并样本进行一般线性模型的对比分析，研究了皮质厚度/认知评分的关系。对存在关系的区域进行了进一步的诊断交互作用研究。在合并样本中，发现额叶、颞叶和枕叶与言语智商、言语学习和执行功能测试之间存在显著的正相关关系。在言语智商与右侧颞枕交界处和左侧中枕叶之间的关系中发现了诊断性交互作用。总之，皮质厚度与神经认知表现之间的显著关系定位于已知与认知有关的脑区。这些关系在患者和对照组中是相似的，除了右侧颞枕和左侧枕叶皮质区域，这表明与健康对照组相比，精神分裂症患者的结构-功能关系受到干扰。
