Department of Dentistry, Taubaté University, Taubaté, SP, Brazil.
J Craniomaxillofac Surg. 2011 Apr;39(3):215-20. doi: 10.1016/j.jcms.2010.03.009. Epub 2010 Apr 24.
Some authors have associated the use of statins, hypolipidemic drugs, and new bone formation. The aim of this work was to evaluate the effect of locally administered simvastatin on bone healing. Bone calvarial defects 5mm in diameter were made in 64 rats. The animals were divided into four groups according to the graft material: the control group, in which the defects were not treated, the SIM-1 group, which received a sponge of collagen soaked with simvastatin (2.2 mg/50 μl), the SIM-2 group, which received a sponge of collagen soaked with simvastatin (0.5 mg/50 μl), and the carrier (CAR) group, which received a sponge of collagen and water. The animals were sacrificed after 30 or 60 days. The skulls were removed, and radiographic densitometry and histometric analyses of the bone defect area were performed. Local crust formation was clinically verified in SIM-1 and SIM-2 animals. After statistical analysis (p<0.05) of bone area data, we observed no significant differences among the groups after 30 days. After 60 days, however, there was less bone formation in the CAR and SIM-2 groups. The SIM-2 group also presented with lower radiographic densities after 60 days. According to the methodology used, we conclude that locally administered simvastatin was detrimental to the repair of defects in the calvaria of rats.
一些作者将他汀类药物（降血脂药物）的使用与新骨形成联系起来。本工作旨在评估局部给予辛伐他汀对骨愈合的影响。在 64 只大鼠的颅骨上制作 5mm 直径的骨缺损。根据移植物的不同，将动物分为四组：对照组，即不治疗的骨缺损；SIM-1 组，即接受辛伐他汀（2.2mg/50μl）浸泡的胶原海绵；SIM-2 组，即接受辛伐他汀（0.5mg/50μl）浸泡的胶原海绵；以及载体（CAR）组，即接受胶原和水浸泡的海绵。30 或 60 天后处死动物。取出颅骨，对骨缺损区域进行放射密度测定和组织计量学分析。在 SIM-1 和 SIM-2 动物中，临床证实有局部结痂形成。对骨面积数据进行统计学分析（p<0.05）后，我们发现 30 天后各组之间无明显差异。然而，60 天后 CAR 和 SIM-2 组的骨形成较少。SIM-2 组在 60 天后的放射密度也较低。根据所用的方法，我们得出结论，局部给予辛伐他汀不利于大鼠颅骨缺损的修复。
