Saifi Aamir Malick, Giraddi Girish B, Ahmed Nausheer
Department of Oral & Maxillofacial Surgery, Government Dental College & Research Institute, Bangalore, India.
Department of Orthodontics, Government Dental College & Research Institute, Bangalore, India.
J Oral Biol Craniofac Res. 2017 May-Aug;7(2):106-112. doi: 10.1016/j.jobcr.2017.04.001. Epub 2017 Apr 17.
The role of simvastatin in lowering serum cholesterol level is well described. However, recent findings suggest they have a role in bone formation as well.
The present prospective study was conducted to evaluate the efficacy of simvastatin on bone formation in extraction sockets.
15 patients undergoing all four first premolar extraction were selected based on inclusion and exclusion criteria. Extraction sockets of left premolars (24 and 34) were considered as cases and right premolars (14 and 44) as controls. Overall 30 extraction sites were assigned to each group. Atraumatic extraction was done in all cases following which simvastatin mixed with gelatin sponge was placed in extraction socket of 24 and 34 while only gelatin sponge was placed in 14 and 44. All sockets were then closed with 3-0 vicryl. The patients were kept on follow-up and complications such as dry socket, pain, and swelling were recorded. Intra oral peri apical radiographs were taken immediately after extraction and at 2nd month and 4th month to record changes in the density of alveolar bone. The radiographic measurements were compared and the differences were statistically analyzed.
Percent increase in bone density at the end of 8th week and 16th week was significantly high in case as compared to the control group.
Local application of simvastatin induces bone formation in extraction sockets. Application is very simple and provides a very cost effective way of faster bone regeneration following tooth extraction.
辛伐他汀降低血清胆固醇水平的作用已得到充分描述。然而，最近的研究结果表明它们在骨形成中也有作用。
本前瞻性研究旨在评估辛伐他汀对拔牙窝骨形成的疗效。
根据纳入和排除标准选择15例接受四颗第一前磨牙拔除的患者。将左侧前磨牙（24和34）的拔牙窝视为病例组，右侧前磨牙（14和44）作为对照组。每组共30个拔牙位点。所有病例均进行无创拔牙，之后将与明胶海绵混合的辛伐他汀置于24和34的拔牙窝中，而14和44仅放置明胶海绵。然后用3-0可吸收缝线关闭所有拔牙窝。对患者进行随访，记录干槽症、疼痛和肿胀等并发症。拔牙后即刻、第2个月和第4个月拍摄口腔内根尖片，记录牙槽骨密度变化。比较影像学测量结果并进行统计学分析。
与对照组相比，病例组在第8周和第16周结束时骨密度的百分比增加显著更高。
局部应用辛伐他汀可诱导拔牙窝骨形成。应用非常简单，为拔牙后更快的骨再生提供了一种非常经济有效的方法。
