Yoshino K, Takahashi K, Eda Y, Nishigaki A, Kitao M
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Mar;43(3):351-4.
Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, elevated serum estrogen and androgen levels, and inappropriate gonadotropin secretion. The present study compares the androgen levels (free testosterone) and catecholamine metabolites (DOPAC as a marker of central dopaminergic activity, DOPEG as one of adrenergic activity) in patients with PCOS and normal controls. The mean serum LH and free testosterone levels of polycystic ovary patients were significantly higher than those of normal controls. The mean DOPEG/DOPAC ratio in the polycystic ovary patients was significantly higher than those of the control group and there was a significant correlation between free testosterone and DOPEG or the DOPEG/DOPAC ratio. It is suggested that, in vivo, norepinephrine excess is present in women with PCOS and that a hyperandrogenemic status is correlated with catecholamine activity.
多囊卵巢综合征（PCOS）的特征是慢性无排卵、血清雌激素和雄激素水平升高以及促性腺激素分泌异常。本研究比较了PCOS患者和正常对照者的雄激素水平（游离睾酮）和儿茶酚胺代谢产物（以3,4-二羟基苯乙酸（DOPAC）作为中枢多巴胺能活性的标志物，以3,4-二羟基苯乙二醇（DOPEG）作为肾上腺素能活性标志物之一）。多囊卵巢患者的血清促黄体生成素（LH）均值和游离睾酮水平显著高于正常对照者。多囊卵巢患者的平均DOPEG/DOPAC比值显著高于对照组，且游离睾酮与DOPEG或DOPEG/DOPAC比值之间存在显著相关性。提示PCOS女性体内存在去甲肾上腺素过量，且高雄激素血症状态与儿茶酚胺活性相关。
